MBTPS1

Gene Symbol	MBTPS1
Entrez Gene	8720
Alt Symbol	PCSK8, S1P, SKI-1
Species	Human
Gene Type	protein-coding
Description	membrane-bound transcription factor peptidase, site 1
Other Description	endopeptidase S1P|membrane-bound transcription factor site-1 protease|proprotein convertase subtilisin/kexin type 8|site-1 protease|subtilisin/kexin isozyme-1
Swissprots	Q14703 Q24JQ2 Q9UF67 A8K6V8
Accessions	CCQ43234 EAW95505 EAW95506 Q14703 AK054744 AK091212 BAG52308 AK291773 BAF84462 AK299067 BAG61133 AL133583 CAB63727 AL701753 BC026330 BC114555 AAI14556 BC114961 AAI14962 BM048055 BM680126 BP364386 BX472644 D42053 BAA07653 NM_003791 NP_003782 NM_201268
Function	Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg- Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. {ECO:0000269|PubMed:21719679}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:9990022}; Single-pass type I membrane protein {ECO:0000269|PubMed:9990022}. Golgi apparatus membrane {ECO:0000269|PubMed:9990022}; Single-pass type I membrane protein {ECO:0000269|PubMed:9990022}. Note=May sort to other organelles, including lysosomal and/or endosomal compartments.
Tissue Specificity	Widely expressed.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human S1P full length protein - ab160161 from Abcam Category Protein Source Wheat germ Species Human

Human S1P protein fragment - ab160162 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human MBTPS1 Protein - H00008720-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MBTPS1 Protein - H00008720-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

MBTPS1 - H00008720-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

MBTPS1 - H00008720-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MBTPS1 - H00008720-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MBTPS1 fusion protein - ag3159 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MBTPS1, His-tagged - MBTPS1-138H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human Membrane-bound transcription factor site-1 protease(MBTPS1) ,p - CSB-YP617930HU CSB-EP617930HU CSB-BP617930HU CSB-MP617930HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MBTPS1 Recombinant Protein Antigen - NBP2-49214PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

MBTPS1 Peptide, Human - M34GP09292H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Membrane-bound transcription factor site-1 protease(MBTPS1),partial - AP74558 from Signalway Antibody Category Protein Prices $155.00, $390.00, $665.00, $1,090.00, $1,835.00, $2,915.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Membrane-bound transcription factor site-1 protease (MBTPS1), Recombinant Protein - MBS9424138 from MyBioSource Category Protein Prices $200.00, $380.00, $610.00, $960.00, $1,570.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg Source E Coli Species Human

Membrane-bound transcription factor site-1 protease (MBTPS1), partial, Recombinant Protein - MBS1443067 from MyBioSource Category Protein Prices $950.00, $950.00, $1,170.00, $1,170.00, $1,390.00, $1,390.00, $1,850.00, $1,850.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MBTPS1 Recombinant Protein (Human) (OPCA04328) - OPCA04328 from Aviva Systems Biology Category Protein Species Human

MBTPS1 fusion protein - Ag26396 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Human MBTPS1 protein - orb383135 from Biorbyt Category Protein Species Human

Recombinant Human MBTPS1 Protein (218-414 aa), His-SUMO-tagged - MBTPS1-2058H from Creative Biomart Category Protein Source E. coli Species Human

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