MBTPS1
| Gene Symbol | MBTPS1 |
|---|---|
| Entrez Gene | 8720 |
| Alt Symbol | PCSK8, S1P, SKI-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | membrane-bound transcription factor peptidase, site 1 |
| Other Description | endopeptidase S1P|membrane-bound transcription factor site-1 protease|proprotein convertase subtilisin/kexin type 8|site-1 protease|subtilisin/kexin isozyme-1 |
| Swissprots | Q14703 Q24JQ2 Q9UF67 A8K6V8 |
| Accessions | CCQ43234 EAW95505 EAW95506 Q14703 AK054744 AK091212 BAG52308 AK291773 BAF84462 AK299067 BAG61133 AL133583 CAB63727 AL701753 BC026330 BC114555 AAI14556 BC114961 AAI14962 BM048055 BM680126 BP364386 BX472644 D42053 BAA07653 NM_003791 NP_003782 NM_201268 |
| Function | Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg- Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. {ECO:0000269|PubMed:21719679}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:9990022}; Single-pass type I membrane protein {ECO:0000269|PubMed:9990022}. Golgi apparatus membrane {ECO:0000269|PubMed:9990022}; Single-pass type I membrane protein {ECO:0000269|PubMed:9990022}. Note=May sort to other organelles, including lysosomal and/or endosomal compartments. |
| Tissue Specificity | Widely expressed. |
| Top Pathways | Protein processing in endoplasmic reticulum |
SKI-1 CRISPR/Cas9 KO Plasmid (h) - sc-402595 from Santa Cruz Biotechnology
|
||||||||
SKI-1 HDR Plasmid (h) - sc-402595-HDR from Santa Cruz Biotechnology
|
||||||||
SKI-1 Double Nickase Plasmid (h) - sc-402595-NIC from Santa Cruz Biotechnology
|
||||||||
SKI-1 Double Nickase Plasmid (h2) - sc-402595-NIC-2 from Santa Cruz Biotechnology
|
||||||||
SKI-1 CRISPR Activation Plasmid (h) - sc-402595-ACT from Santa Cruz Biotechnology
|
||||||||
SKI-1 CRISPR Activation Plasmid (h2) - sc-402595-ACT-2 from Santa Cruz Biotechnology
|
||||||||
SKI-1 Lentiviral Activation Particles (h) - sc-402595-LAC from Santa Cruz Biotechnology
|
||||||||
SKI-1 Lentiviral Activation Particles (h2) - sc-402595-LAC-2 from Santa Cruz Biotechnology
|
||||||||
SKI-1 siRNA (h) - sc-36496 from Santa Cruz Biotechnology
|
||||||||
SKI-1 shRNA Plasmid (h) - sc-36496-SH from Santa Cruz Biotechnology
|
||||||||
SKI-1 shRNA (h) Lentiviral Particles - sc-36496-V from Santa Cruz Biotechnology
|
||||||||
MBTPS1 RNAi - H00008720-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU071921 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN13095 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13095 from Sigma-Aldrich
|
||||||||
MBTPS1 siRNA (Human) - CRH5740 from Cohesion Biosciences
|
||||||||
MBTPS1 RNAi - H00008720-R01 from Novus Biologicals
|
||||||||
shRNA set against Human MBTPS1 (NM_003791.2) - SHH339003 from Creative biogene
|
||||||||
shRNA set against Human MBTPS1(NM_003791.2) - SHH180101 from Creative biogene
|
||||||||
Human MBTPS1 siRNA - orb266242 from Biorbyt
|
||||||||
MBTPS1 shRNA Plasmid (Human) - CHH5740 from Cohesion Biosciences
|
||||||||
MBTPS1 miRNA 3'UTR clone - MiUTR1H-06149 from Creative biogene
|