| Gene Symbol |
YBX1
|
| Entrez Gene |
4904
|
| Alt Symbol |
BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Y box binding protein 1
|
| Other Description |
CBF-A|CCAAT-binding transcription factor I subunit A|DNA-binding protein B|EFI-A|Y-box transcription factor|Y-box-binding protein 1|enhancer factor I subunit A|major histocompatibility complex, class II, Y box-binding protein I|nuclease sensitive element binding protein 1|nuclease-sensitive element-binding protein 1
|
| Swissprots |
Q5FVF0 Q15325 Q14972 P67809
|
| Accessions |
CAA65446 EAX07148 EAX07149 P67809 AK309996 AK311708 BC000064 AAH00064 BC002411 AAH02411 BC010430 AAH10430 BC013838 BC015208 AAH15208 BC018393 AAH18393 BC020164 AAH20164 BC038384 AAH38384 BC065571 AAH65571 BC070084 AAH70084 BC071708 AAH71708 BC072014 AAH72014 BC090038 AAH90038 BC098435 AAH98435 BC106045 AAI06046 CN353145 DQ891609 ABM82535 DQ894802 ABM85728 J03827 AAA61308 L28809 AAA20871 M24070 AAA35750 M83234 AAA59949 M85234 AAA36569 Z70765 XM_005270904 XP_005270961 NM_004559 NP_004550
|
| Function |
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Cytoplasmic granule {ECO:0000269|PubMed:25229427}. Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress.
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