YBX1

Gene Symbol	YBX1
Entrez Gene	4904
Alt Symbol	BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1
Species	Human
Gene Type	protein-coding
Description	Y box binding protein 1
Other Description	CBF-A|CCAAT-binding transcription factor I subunit A|DNA-binding protein B|EFI-A|Y-box transcription factor|Y-box-binding protein 1|enhancer factor I subunit A|major histocompatibility complex, class II, Y box-binding protein I|nuclease sensitive element binding protein 1|nuclease-sensitive element-binding protein 1
Swissprots	Q5FVF0 Q15325 Q14972 P67809
Accessions	CAA65446 EAX07148 EAX07149 P67809 AK309996 AK311708 BC000064 AAH00064 BC002411 AAH02411 BC010430 AAH10430 BC013838 BC015208 AAH15208 BC018393 AAH18393 BC020164 AAH20164 BC038384 AAH38384 BC065571 AAH65571 BC070084 AAH70084 BC071708 AAH71708 BC072014 AAH72014 BC090038 AAH90038 BC098435 AAH98435 BC106045 AAI06046 CN353145 DQ891609 ABM82535 DQ894802 ABM85728 J03827 AAA61308 L28809 AAA20871 M24070 AAA35750 M83234 AAA59949 M85234 AAA36569 Z70765 XM_005270904 XP_005270961 NM_004559 NP_004550
Function	Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. {ECO:0000250}.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasmic granule {ECO:0000269|PubMed:25229427}. Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® YB1 siRNA II - 6207 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® YB1 siRNA I - 6206 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

YB-1 CRISPR/Cas9 KO Plasmid (h) - sc-401385 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

YB-1 HDR Plasmid (h) - sc-401385-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

YB-1 Double Nickase Plasmid (h) - sc-401385-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

YB-1 Double Nickase Plasmid (h2) - sc-401385-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

YB-1 CRISPR Activation Plasmid (h) - sc-401385-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

YB-1 CRISPR Activation Plasmid (h2) - sc-401385-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

YB-1 Lentiviral Activation Particles (h) - sc-401385-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

YB-1 Lentiviral Activation Particles (h2) - sc-401385-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

YB-1 siRNA (h) - sc-38634 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

YB-1 shRNA Plasmid (h) - sc-38634-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

YB-1 shRNA (h) Lentiviral Particles - sc-38634-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

YB1 RNAi - H00004904-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU148801 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22999 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22999 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

YBX1 siRNA (Human) - CRH3259 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

YBX1 - MBS827147 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

YBX1 shRNA Plasmid (Human) - CHH3259 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

YBX1 miRNA 3'UTR clone - MiUTR1H-11331 from Creative biogene Species Reactivities Human

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