YBX1

Gene Symbol	YBX1
Entrez Gene	4904
Alt Symbol	BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1
Species	Human
Gene Type	protein-coding
Description	Y box binding protein 1
Other Description	CBF-A|CCAAT-binding transcription factor I subunit A|DNA-binding protein B|EFI-A|Y-box transcription factor|Y-box-binding protein 1|enhancer factor I subunit A|major histocompatibility complex, class II, Y box-binding protein I|nuclease sensitive element binding protein 1|nuclease-sensitive element-binding protein 1
Swissprots	Q5FVF0 Q15325 Q14972 P67809
Accessions	CAA65446 EAX07148 EAX07149 P67809 AK309996 AK311708 BC000064 AAH00064 BC002411 AAH02411 BC010430 AAH10430 BC013838 BC015208 AAH15208 BC018393 AAH18393 BC020164 AAH20164 BC038384 AAH38384 BC065571 AAH65571 BC070084 AAH70084 BC071708 AAH71708 BC072014 AAH72014 BC090038 AAH90038 BC098435 AAH98435 BC106045 AAI06046 CN353145 DQ891609 ABM82535 DQ894802 ABM85728 J03827 AAA61308 L28809 AAA20871 M24070 AAA35750 M83234 AAA59949 M85234 AAA36569 Z70765 XM_005270904 XP_005270961 NM_004559 NP_004550
Function	Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. {ECO:0000250}.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasmic granule {ECO:0000269|PubMed:25229427}. Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human YB1 (phospho S102) peptide - ab74644 from Abcam Category Peptide

Human YB1 full length protein - ab187443 from Abcam Category Protein Source E. coli Species Human

Human YB1 peptide - ab74645 from Abcam Category Peptide

YB1 peptide - ab12411 from Abcam Category Peptide

YBX1-Blocking Peptide - ab175051 from Abcam Category Peptide

YBX1 / YB1 Antibody Blocking Peptide - LS-E12188 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

YBX1 / YB1 Antibody Blocking Peptide - LS-E12189 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

YBX1 / YB1 Antibody Blocking Peptide - LS-E8191 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

YBX1 / YB1 Antibody Blocking Peptide - LS-E8190 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

YB1 Partial Recombinant Protein - H00004904-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human YB1 Protein - H00004904-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human YB1 Protein - NBP2-30101 from Novus Biologicals Category Protein Prices $269.00, $749.00 Sizes 100 µg, 500 µg Source E. coli Species Human

YB1 Peptide - P1919 from Novus Biologicals Category Peptide Species Human

YB1 Peptide - P1918 from Novus Biologicals Category Peptide Species Human

YBX1-Antibody-C-term-Blocking-Peptide - BP6295b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

YB1-YBX1-Antibody-N-term-Blocking-peptide - BP6295a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

YBX1 protein (His tag) - 80R-3994 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

YBX1 (1-324, His-tag) - AR51679PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

YBX1 (1-324, His-tag) - AR51679PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

YBX1 - H00004904-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

YBX1 - H00004904-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

YBX1 - H00004904-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

YBX1 fusion protein - Ag14129 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human YBX1, His-tagged - YBX1-30136TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human YBX1, GST-tagged - YBX1-4839H from Creative Biomart Category Protein Source Wheat germ Species Human

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