YBX1

Gene Symbol YBX1
Entrez Gene 4904
Alt Symbol BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1
Species Human
Gene Type protein-coding
Description Y box binding protein 1
Other Description CBF-A|CCAAT-binding transcription factor I subunit A|DNA-binding protein B|EFI-A|Y-box transcription factor|Y-box-binding protein 1|enhancer factor I subunit A|major histocompatibility complex, class II, Y box-binding protein I|nuclease sensitive element binding protein 1|nuclease-sensitive element-binding protein 1
Swissprots Q5FVF0 Q15325 Q14972 P67809
Accessions CAA65446 EAX07148 EAX07149 P67809 AK309996 AK311708 BC000064 AAH00064 BC002411 AAH02411 BC010430 AAH10430 BC013838 BC015208 AAH15208 BC018393 AAH18393 BC020164 AAH20164 BC038384 AAH38384 BC065571 AAH65571 BC070084 AAH70084 BC071708 AAH71708 BC072014 AAH72014 BC090038 AAH90038 BC098435 AAH98435 BC106045 AAI06046 CN353145 DQ891609 ABM82535 DQ894802 ABM85728 J03827 AAA61308 L28809 AAA20871 M24070 AAA35750 M83234 AAA59949 M85234 AAA36569 Z70765 XM_005270904 XP_005270961 NM_004559 NP_004550
Function Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. {ECO:0000250}.
Subcellular Location Cytoplasm. Nucleus. Cytoplasmic granule {ECO:0000269|PubMed:25229427}. Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress.

Phospho-YB1 (Ser102) (C34A2) Rabbit mAb - 2900 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C34A2
Western blot analysis of extracts from MCF-7 cells, serum-starved overnight and then either left untreated or treated with IGF-1 (50 ng/ml) for one hour, using Phospho-YB1 (Ser102) (C34A2) Rabbit mAb (upper) or YB1 Antibody #2749 (lower). Further treatment of the IGF-1-treated cell extracts with λ phosphatase depleted the phospho-specific YB1 signal (upper), but not total YB1 (lower).

YB1 (D2A11) Rabbit mAb - 9744 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2A11
Western blot analysis of extracts from various cell lines using YB1 (D2A11) Rabbit mAb.

YB1 (D2B12) Rabbit mAb - 8475 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2B12
Western blot analysis of extracts from various cell lines using YB1 (D2B12) Rabbit mAb.

YB1 (D299) Antibody - 4202 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using YB1 (D299) Antibody.

YB1 Antibody - 2749 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from HeLa, NIH/3T3, C6 and COS cells using YB1 Antibody.

YB-1 (C-3) - sc-398340 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
YB-1 (C-3): sc-398340. Western blot analysis of YB-1 expression in MCF7 (A) and SW480 (B) whole cell lysates.

YB-1 (E-7) - sc-398146 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
YB-1 (E-7): sc-398146. Western blot analysis of YB-1 expression in MCF7 (A) and SW480 (B) whole cell lysates.

YB-1 (A-16) - sc-18057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
YB-1 (A-16): sc-18057. Western blot analysis of YB-1 expression in HeLa (A) and K-562 (B) whole cell lysates.

YB-1 (H-45) - sc-292740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

YB-1 (59-Q) - sc-101198 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
YB-1 (59-Q): sc-101198. Western blot analysis of YB-1 expression in non-transfected 293T: sc-117752 (A), human YB-1 transfected 293T: sc-113221 (B) and HeLa (C) whole cell lysates.

Anti-YB1 (phospho S102) antibody - ab138654 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-YB1 (phospho S102) antibody (ab138654) at 1/500 dilution + HepG2 cell extract (from cells treated with PMA at 125ng/ml for 15 minutes) at 30 µg

Anti-YB1 antibody - ab12148 from Abcam

Prices $401.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-YB1 antibody (ab12148) at 1 µg/ml + HEK293 Whole Cell Lysate Transiently Overexpressing YB1 at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-YB1 antibody [EP2706Y] - ab76540 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2706Y
Flow cytometric analysis of permeabilized HeLa cells using ab76540 at 1/60 dilution (red) or a rabbit IgG (negative) (green)

Anti-YB1 antibody [EP2708Y] - ab76149 from Abcam

Prices $392.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2708Y
All lanes : Anti-YB1 antibody [EP2708Y] (ab76149) at 1/200000 dilutionLane 1 : HeLa cell lysateLane 2 : SW480 cell lysateLane 3 : A549 cell lysateLane 4 : MCF7 cell lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/1000 dilution

Anti-YB1 antibody - Aminoterminal end - ab71557 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-YB1 antibody - Aminoterminal end (ab71557) at 1/60 dilution + NCI-H460 cell line lysate at 30 µg

Anti-YBX1 / YB1 Antibody (C-Terminus) - LS-C122232 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-YBX1 / YB1 Antibody (N-Terminus) - LS-C144945 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-YBX1 / YB1 Antibody - LS-C190163 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-YBX1 / YB1 Antibody (clone 21A3) - LS-C193619 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 21A3

Anti-YBX1 / YB1 Antibody (aa236-285) - LS-C29829 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-YBX1 / YB1 Antibody (aa149-178, AP) - LS-C273778 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-YBX1 / YB1 Antibody (aa149-178, Biotin) - LS-C273780 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-YBX1 / YB1 Antibody (aa149-178, APC) - LS-C273779 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-YBX1 / YB1 Antibody (aa149-178, FITC) - LS-C273781 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-YBX1 / YB1 Antibody (aa149-178, PE) - LS-C273784 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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