Gene Symbol | SERPINC1 |
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Entrez Gene | 462 |
Alt Symbol | AT3, AT3D, ATIII, THPH7 |
Species | Human |
Gene Type | protein-coding |
Description | serpin peptidase inhibitor, clade C (antithrombin), member 1 |
Other Description | antithrombin-III|serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 |
Swissprots | Q13815 B2R6P0 Q9UC78 P78439 P78447 P01008 Q5TC78 Q7KZ97 Q7KZ43 |
Accessions | AAA19930 AAA51793 AAA51794 AAA51795 AAA51796 AAB19468 AAB23132 AAB40025 AAK60337 AAZ38825 BAC21173 BAC21174 BAC21175 BAC21176 CAA25059 CAA25060 CAA26951 CAA26952 CAA48690 CAI45858 CBX54631 EAW90969 EAW90970 EAW90971 P01008 AF130100 AAG35525 AK312654 BAG35537 BC022309 AAH22309 D29832 BAA06212 H62671 H65301 H71210 R84868 XM_005245198 XP_005245255 NM_000488 NP_000479 |
Function | Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. {ECO:0000269|PubMed:15853774}. |
Subcellular Location | Secreted, extracellular space. |
Tissue Specificity | Found in plasma. |
Top Pathways | Complement and coagulation cascades |
ATIII CRISPR/Cas9 KO Plasmid (h) - sc-403735 from Santa Cruz Biotechnology
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ATIII HDR Plasmid (h) - sc-403735-HDR from Santa Cruz Biotechnology
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ATIII Double Nickase Plasmid (h) - sc-403735-NIC from Santa Cruz Biotechnology
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ATIII Double Nickase Plasmid (h2) - sc-403735-NIC-2 from Santa Cruz Biotechnology
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ATIII CRISPR Activation Plasmid (h) - sc-403735-ACT from Santa Cruz Biotechnology
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ATIII CRISPR Activation Plasmid (h2) - sc-403735-ACT-2 from Santa Cruz Biotechnology
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ATIII Lentiviral Activation Particles (h) - sc-403735-LAC from Santa Cruz Biotechnology
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ATIII Lentiviral Activation Particles (h2) - sc-403735-LAC-2 from Santa Cruz Biotechnology
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ATIII siRNA (h) - sc-44839 from Santa Cruz Biotechnology
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ATIII shRNA Plasmid (h) - sc-44839-SH from Santa Cruz Biotechnology
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ATIII shRNA (h) Lentiviral Particles - sc-44839-V from Santa Cruz Biotechnology
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Serpin C1/Antithrombin-III RNAi - H00000462-R01 from Novus Biologicals
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MISSION® esiRNA - EHU088791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19150 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19150 from Sigma-Aldrich
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SERPINC1 siRNA (Human) - CRH0322 from Cohesion Biosciences
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SERPINC1 - MBS8219877 from MyBioSource
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shRNA set against Human SERPINC1 (NM_000488.3) - SHH405324 from Creative biogene
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SERPINC1 shRNA Plasmid (Human) - CHH0322 from Cohesion Biosciences
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SERPINC1 miRNA 3'UTR clone - MiUTR3H-00160 from Creative biogene
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