| Gene Symbol |
USP3
|
| Entrez Gene |
9960
|
| Alt Symbol |
SIH003, UBP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 3
|
| Other Description |
deubiquitinating enzyme 3|ubiquitin carboxyl-terminal hydrolase 3|ubiquitin thioesterase 3|ubiquitin thiolesterase 3|ubiquitin-specific-processing protease 3
|
| Swissprots |
B4DVU5 Q9Y6I4 F5H1A6 Q8WVD0
|
| Accessions |
EAW77651 Q9Y6I4 AF073344 AAD42992 AF077040 AAD27773 AI695842 AK022931 BAG51139 AK094444 AK300948 BAG62577 AK301236 BAG62807 AK301563 BAG63058 AK307810 AK309382 AK314223 AY461579 AAT37507 BC018113 AAH18113 BC065300 AAH65300 BC100029 AAI00030 BC107137 AAI07138 BC107138 AAI07139 BT007269 AAP35933 BX647760 DA557812 DQ891025 ABM81951 DQ894205 ABM85131 XM_006720789 XP_006720852 XM_006720790 XP_006720853 XM_006720791 XP_006720854 XM_011522265 XP_011520567 XM_011522266 XP_011520568 NM_001256702 NP_001243631 NM_006537 NP_006528 NR_046341 NR_046342
|
| Function |
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. {ECO:0000269|PubMed:17980597}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17980597}. Note=Localizes preferentially with monoubiquitinated H2A to chromatin.
|
| Tissue Specificity |
Expressed in all tissues examined, with strongest expression in pancreas.
|