USP3

Gene Symbol USP3
Entrez Gene 9960
Alt Symbol SIH003, UBP
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 3
Other Description deubiquitinating enzyme 3|ubiquitin carboxyl-terminal hydrolase 3|ubiquitin thioesterase 3|ubiquitin thiolesterase 3|ubiquitin-specific-processing protease 3
Swissprots B4DVU5 Q9Y6I4 F5H1A6 Q8WVD0
Accessions EAW77651 Q9Y6I4 AF073344 AAD42992 AF077040 AAD27773 AI695842 AK022931 BAG51139 AK094444 AK300948 BAG62577 AK301236 BAG62807 AK301563 BAG63058 AK307810 AK309382 AK314223 AY461579 AAT37507 BC018113 AAH18113 BC065300 AAH65300 BC100029 AAI00030 BC107137 AAI07138 BC107138 AAI07139 BT007269 AAP35933 BX647760 DA557812 DQ891025 ABM81951 DQ894205 ABM85131 XM_006720789 XP_006720852 XM_006720790 XP_006720853 XM_006720791 XP_006720854 XM_011522265 XP_011520567 XM_011522266 XP_011520568 NM_001256702 NP_001243631 NM_006537 NP_006528 NR_046341 NR_046342
Function Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. {ECO:0000269|PubMed:17980597}.
Subcellular Location Nucleus {ECO:0000269|PubMed:17980597}. Note=Localizes preferentially with monoubiquitinated H2A to chromatin.
Tissue Specificity Expressed in all tissues examined, with strongest expression in pancreas.

USP3 (K-19) - sc-79318 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
USP3 (K-19): sc-79318. Western blot analysis of USP3 expression in non-transfected: sc-117752 (A) and human USP3 transfected: sc-112418 (B) 293T whole cell lysates.

USP3 (Y-16) - sc-79319 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

USP3 (8L8) - sc-135597 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
USP3 (8L8): sc-135597. Western blot analysis of USP3 expression in human USP3 transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-USP3 antibody - ab82935 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab82935 stained HeLa cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab82935 at 5µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-USP3 antibody - ab101473 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-USP3 antibody (ab101473) at 1 µg/mlLane 1 : U2OS (Human osteosarcoma cell line) Whole Cell Lysate Lane 2 : : HeLa (Human epithelial carcinoma cell line) Nuclear LysateLane 3 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-USP3 antibody - ab80597 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling USP3 with ab80597 at 1/1000 (1µg/ml). Detection: DAB.

Anti-USP3 antibody - ab84702 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84702, at 1/100 dilution, staining USP3 in formalin-fixed, paraffin-embedded human ovarian carcinoma by Immunohistochemistry using a Red fluorescent goat anti-rabbit IgG highly cross adsorbed Hilyte PlusTM 555 secondary antibody at a dilution of 1/100.

Anti-USP3 antibody - ab56901 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56901 USP3 antibody at 1ug/ml.

Anti-USP3 / UBP Antibody - LS-C86283 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (AP) - LS-C87139 from LifeSpan Bioscience

Prices $755.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (AP) - LS-C87140 from LifeSpan Bioscience

Prices $755.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (N-Terminus, APC) - LS-C221057 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (N-Terminus, Azide-free, HRP) - LS-C221060 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (N-Terminus, Biotin) - LS-C221058 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (N-Terminus, FITC) - LS-C221059 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (C-Terminus, APC) - LS-C221062 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (N-Terminus, PE) - LS-C221061 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (C-Terminus, FITC) - LS-C221064 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (C-Terminus, Biotin) - LS-C221063 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (C-Terminus, PE) - LS-C221065 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (C-Terminus, Azide-free, HRP) - LS-C221066 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (aa325-375) - LS-C288333 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (C-Terminus) - LS-C329042 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (N-Terminus) - LS-C330726 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP3 / UBP Antibody (aa180-229) - LS-C101455 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
USP3 antibody LS-C101455 Western blot of Jurkat lysate.
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