| Gene Symbol |
MMP17
|
| Entrez Gene |
4326
|
| Alt Symbol |
MT4-MMP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
matrix metallopeptidase 17 (membrane-inserted)
|
| Other Description |
MMP-17|MT-MMP 4|MT4MMP|MTMMP4|matrix metalloproteinase 17 (membrane-inserted)|matrix metalloproteinase-17|membrane-type matrix metalloproteinase 4|membrane-type-4 matrix metalloproteinase
|
| Swissprots |
Q14850 Q9ULZ9
|
| Accessions |
EAW98528 Q9ULZ9 AB021225 BAA82707 BC040507 AAH40507 BC045610 AAH45610 BX389435 CA489162 X89576 CAA61753 XM_011538355 XP_011536657 XM_011538356 XP_011536658 XM_011538357 XP_011536659 XR_944550 XR_944551 XR_944552 NM_016155 NP_057239
|
| Function |
Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
|
| Subcellular Location |
Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
|
| Tissue Specificity |
Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.
|