PORCN

Gene Symbol PORCN
Entrez Gene 64840
Alt Symbol DHOF, FODH, MG61, PORC, PPN
Species Human
Gene Type protein-coding
Description porcupine homolog (Drosophila)
Other Description probable protein-cysteine N-palmitoyltransferase porcupine|protein-cysteine N-palmitoyltransferase porcupine
Swissprots Q9H236 B7ZAR3 Q9H234 Q14829 B2RBN8 Q9UJU7 Q9H237 Q9H235
Accessions EAW50777 EAW50778 EAW50779 EAW50780 EAW50781 Q9H237 AF317058 AAG39628 AF317059 AAG39629 AF317060 AAG39630 AF317061 AAG39631 AK056340 AK057727 BAG51958 AK293347 BAG56863 AK314745 BAG37285 AK316378 BAH14749 AL538245 AL579208 BC019080 AAH19080 BM543485 BM545893 CN310467 DQ892632 ABM83558 DQ895869 ABM86795 HY002842 L08239 AAA74510 XM_005272635 XP_005272692 XM_005272636 XP_005272693 XM_005272637 XP_005272694 XM_006724544 XP_006724607 XM_006724545 XP_006724608 XM_006724546 XP_006724609 XM_006724547 XP_006724610 XM_011543948 XP_011542250 NM_001282167 NP_001269096 NM_022825 NP_073736 NM_203473 NP_982299 NM_203474 NP_982300 NM_203475 NP_982301 NM_203476
Function protein-cysteine N-palmitoyltransferase that modulates the processing of Wnt proteins by mediating serine palmitoylation of Wnt family members. {ECO:0000269|PubMed:12034504, ECO:0000269|PubMed:20826466, ECO:0000269|PubMed:24292069}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Isoform 1 is expressed in fetal brain, brain, amygdala, caudate nucleus, cerebellum, hippocampus, pituitary, thalamus, heart, skeletal muscle and testis. Isoform 4 is expressed in amygdala, corpus callosum, hippocampus, spinal cord, kidney, liver, lung, spleen, uterus, testis. Isoform 2 and isoform 3 are expressed in substantia negra, spinal cord, heart and lung. {ECO:0000269|PubMed:12034504}.
Top Pathways Wnt signaling pathway

PORCN-Over-expression-Lysate - LY13720a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag PORCN (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PORCN gene

PORCN overexpression lysate - LY403716 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

PORCN overexpression lysate - LY404284 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

PORCN overexpression lysate - LY404285 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

PORCN Overexpression Lysate (Native) - NBP2-04552 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: PORCN Overexpression Lysate (Adult Normal) [NBP2-04552] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PORCN.

PORCN Overexpression Lysate (Native) - NBP2-04454 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: PORCN Overexpression Lysate (Adult Normal) [NBP2-04454] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PORCN.

Panoply™ Human PORCN Knockdown Stable Cell Line - CSC-DC012135 from Creative biogene

Category Cell Line
Species Human
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