| Gene Symbol | PORCN |
|---|---|
| Entrez Gene | 64840 |
| Alt Symbol | DHOF, FODH, MG61, PORC, PPN |
| Species | Human |
| Gene Type | protein-coding |
| Description | porcupine homolog (Drosophila) |
| Other Description | probable protein-cysteine N-palmitoyltransferase porcupine|protein-cysteine N-palmitoyltransferase porcupine |
| Swissprots | Q9H236 B7ZAR3 Q9H234 Q14829 B2RBN8 Q9UJU7 Q9H237 Q9H235 |
| Accessions | EAW50777 EAW50778 EAW50779 EAW50780 EAW50781 Q9H237 AF317058 AAG39628 AF317059 AAG39629 AF317060 AAG39630 AF317061 AAG39631 AK056340 AK057727 BAG51958 AK293347 BAG56863 AK314745 BAG37285 AK316378 BAH14749 AL538245 AL579208 BC019080 AAH19080 BM543485 BM545893 CN310467 DQ892632 ABM83558 DQ895869 ABM86795 HY002842 L08239 AAA74510 XM_005272635 XP_005272692 XM_005272636 XP_005272693 XM_005272637 XP_005272694 XM_006724544 XP_006724607 XM_006724545 XP_006724608 XM_006724546 XP_006724609 XM_006724547 XP_006724610 XM_011543948 XP_011542250 NM_001282167 NP_001269096 NM_022825 NP_073736 NM_203473 NP_982299 NM_203474 NP_982300 NM_203475 NP_982301 NM_203476 |
| Function | protein-cysteine N-palmitoyltransferase that modulates the processing of Wnt proteins by mediating serine palmitoylation of Wnt family members. {ECO:0000269|PubMed:12034504, ECO:0000269|PubMed:20826466, ECO:0000269|PubMed:24292069}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Isoform 1 is expressed in fetal brain, brain, amygdala, caudate nucleus, cerebellum, hippocampus, pituitary, thalamus, heart, skeletal muscle and testis. Isoform 4 is expressed in amygdala, corpus callosum, hippocampus, spinal cord, kidney, liver, lung, spleen, uterus, testis. Isoform 2 and isoform 3 are expressed in substantia negra, spinal cord, heart and lung. {ECO:0000269|PubMed:12034504}. |
| Top Pathways | Wnt signaling pathway |
PORCN CRISPR/Cas9 KO Plasmid (h) - sc-413044 from Santa Cruz Biotechnology
|
||||||||
PORCN HDR Plasmid (h) - sc-413044-HDR from Santa Cruz Biotechnology
|
||||||||
PORCN Double Nickase Plasmid (h) - sc-413044-NIC from Santa Cruz Biotechnology
|
||||||||
PORCN Double Nickase Plasmid (h2) - sc-413044-NIC-2 from Santa Cruz Biotechnology
|
||||||||
PORCN CRISPR Activation Plasmid (h) - sc-413044-ACT from Santa Cruz Biotechnology
|
||||||||
PORCN CRISPR Activation Plasmid (h2) - sc-413044-ACT-2 from Santa Cruz Biotechnology
|
||||||||
PORCN Lentiviral Activation Particles (h) - sc-413044-LAC from Santa Cruz Biotechnology
|
||||||||
PORCN Lentiviral Activation Particles (h2) - sc-413044-LAC-2 from Santa Cruz Biotechnology
|
||||||||
PORCN siRNA (h) - sc-90930 from Santa Cruz Biotechnology
|
||||||||
PORCN shRNA Plasmid (h) - sc-90930-SH from Santa Cruz Biotechnology
|
||||||||
PORCN shRNA (h) Lentiviral Particles - sc-90930-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU089161 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1290 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1290 from Sigma-Aldrich
|
||||||||
PORCN siRNA (Human) - CRJ2111 from Cohesion Biosciences
|
||||||||
shRNA set against Human PORCN (NM_022825.2) - SHH379896 from Creative biogene
|
||||||||
shRNA set against Human PORCN(NM_203473.1) - SHR129300 from Creative biogene
|
||||||||
shRNA set against Human PORCN(NM_022825.2) - SHR129318 from Creative biogene
|
||||||||
shRNA set against Human PORCN(NM_203474.1) - SHR129336 from Creative biogene
|
||||||||
shRNA set against Human PORCN(NM_203475.1) - SHR129354 from Creative biogene
|
||||||||
Human PORCN siRNA - orb272612 from Biorbyt
|
||||||||
PORCN shRNA Plasmid (Human) - CHJ2111 from Cohesion Biosciences
|
||||||||
PORCN miRNA 3'UTR clone - MiUTR1H-08102 from Creative biogene
|
||||||||
PORCN miRNA 3'UTR clone - MiUTR1H-08103 from Creative biogene
|
||||||||
PORCN miRNA 3'UTR clone - MiUTR1H-08104 from Creative biogene
|