| Gene Symbol |
FBXW8
|
| Entrez Gene |
26259
|
| Alt Symbol |
FBW6, FBW8, FBX29, FBXO29, FBXW6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box and WD repeat domain containing 8
|
| Other Description |
F-box and WD-40 domain protein 8|F-box and WD-40 domain-containing protein 8|F-box only protein 29|F-box/WD repeat-containing protein 8
|
| Swissprots |
Q8N3Y1 Q9UK95
|
| Accessions |
EAW98094 EAW98095 EAW98096 EAW98097 Q8N3Y1 AF176707 AAF03129 AK055849 AK289621 BAF82310 BC037296 AAH37296 BC045190 XM_005253866 XP_005253923 XM_005253867 XP_005253924 XM_005253868 XP_005253925 XM_011538172 XP_011536474 XR_944517 XR_944518 NM_012174 NP_036306 NM_153348 NP_699179
|
| Function |
Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000269|PubMed:18498745, ECO:
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:21572988}. Golgi apparatus {ECO:0000269|PubMed:21572988}. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {ECO:0000250}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|