FBXW8

Gene Symbol	FBXW8
Entrez Gene	26259
Alt Symbol	FBW6, FBW8, FBX29, FBXO29, FBXW6
Species	Human
Gene Type	protein-coding
Description	F-box and WD repeat domain containing 8
Other Description	F-box and WD-40 domain protein 8|F-box and WD-40 domain-containing protein 8|F-box only protein 29|F-box/WD repeat-containing protein 8
Swissprots	Q8N3Y1 Q9UK95
Accessions	EAW98094 EAW98095 EAW98096 EAW98097 Q8N3Y1 AF176707 AAF03129 AK055849 AK289621 BAF82310 BC037296 AAH37296 BC045190 XM_005253866 XP_005253923 XM_005253867 XP_005253924 XM_005253868 XP_005253925 XM_011538172 XP_011536474 XR_944517 XR_944518 NM_012174 NP_036306 NM_153348 NP_699179
Function	Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000269|PubMed:18498745, ECO:
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000269|PubMed:21572988}. Golgi apparatus {ECO:0000269|PubMed:21572988}. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {ECO:0000250}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FBXW8 protein fragment - ab161946 from Abcam Category Protein Source Wheat germ Species Human

FBXW8 Antibody Blocking Peptide - LS-E438 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBXW8 Antibody Blocking Peptide - LS-E20094 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FBXW8 Protein - H00026259-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FBXW8-Antibody-Center-Blocking-peptide - BP10719c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FBXW8 Blocking Peptide - 33R-8072 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FBXW8 Blocking Peptide - 33R-6260 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FBXW8 - H00026259-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FBXW8 - H00026259-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human F-box/WD repeat-containing protein 8(FBXW8) - CSB-YP847627HU CSB-EP847627HU CSB-BP847627HU CSB-MP847627HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FBXW8 Recombinant Protein Antigen - NBP2-38429PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FBXW8 Recombinant Protein Antigen - NBP1-84715PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FBXW8 Peptide, Human - M34GP05628H from Creative Peptides Category Peptide Source Synthetic. Species Human

F-box/WD repeat-containing protein 8 (FBXW8), Recombinant Protein - MBS1467921 from MyBioSource Category Protein Prices $1,400.00, $1,400.00, $1,620.00, $1,620.00, $2,340.00, $2,340.00, $2,785.00, $2,785.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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