FBXW8

Gene Symbol	FBXW8
Entrez Gene	26259
Alt Symbol	FBW6, FBW8, FBX29, FBXO29, FBXW6
Species	Human
Gene Type	protein-coding
Description	F-box and WD repeat domain containing 8
Other Description	F-box and WD-40 domain protein 8|F-box and WD-40 domain-containing protein 8|F-box only protein 29|F-box/WD repeat-containing protein 8
Swissprots	Q8N3Y1 Q9UK95
Accessions	EAW98094 EAW98095 EAW98096 EAW98097 Q8N3Y1 AF176707 AAF03129 AK055849 AK289621 BAF82310 BC037296 AAH37296 BC045190 XM_005253866 XP_005253923 XM_005253867 XP_005253924 XM_005253868 XP_005253925 XM_011538172 XP_011536474 XR_944517 XR_944518 NM_012174 NP_036306 NM_153348 NP_699179
Function	Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000269|PubMed:18498745, ECO:
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000269|PubMed:21572988}. Golgi apparatus {ECO:0000269|PubMed:21572988}. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {ECO:0000250}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FBXO29 (A-14) - sc-167861 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

FBXO29 (H-41) - sc-382561 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

FBXO29 (S-14) - sc-167863 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

FBXO29 (T-15) - sc-167864 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-FBXW8 antibody - ab85647 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FBXW8 antibody - ab183753 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FBXW8 antibody - ab195603 from Abcam Prices $370.00 Sizes 250 µg Host Rabbit Clonality Polyclonal

Anti-FBXW8 Antibody (aa504-553) - LS-C102670 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FBXW8 Antibody (aa270-299, FITC) - LS-C246939 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FBXW8 Antibody (aa270-299, PE) - LS-C246940 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FBXW8 Antibody (aa270-299, Azide-free, HRP) - LS-C249980 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FBXW8 Antibody (C-Terminus) - LS-C116624 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FBXW8 Antibody - LS-C178371 from LifeSpan Bioscience Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FBXW8 Antibody (aa273-303) - LS-C321332 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FBXW8 Antibody (aa270-299) - LS-C166096 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-FBXW8 Antibody (aa270-299, AP) - LS-C246936 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FBXW8 Antibody (aa270-299, APC) - LS-C246937 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FBXW8 Antibody (aa270-299, Biotin) - LS-C246938 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

FBXW8 Antibody - NBP1-84715 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FBXW8 Antibody - NBP1-56338 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FBXW8 Antibody - H00026259-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

FBXW8 Antibody - NBP2-38429 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FBXW8 Polyclonal Antibody - bs-8395R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FBXW8 antibody produced in rabbit - HPA038851 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FBXW8 antibody produced in rabbit - SAB2100801 from Sigma-Aldrich Prices $347.50 Sizes 50 µg Host Rabbit Clonality Polyclonal

Search more