| Gene Symbol |
LRP1
|
| Entrez Gene |
4035
|
| Alt Symbol |
A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
low density lipoprotein receptor-related protein 1
|
| Other Description |
LRP-1|TbetaR-V/LRP-1/IGFBP-3 receptor|alpha-2-macroglobulin receptor|apolipoprotein E receptor|prolow-density lipoprotein receptor-related protein 1|type V tgf-beta receptor
|
| Swissprots |
Q8IVG8 Q07954 Q86SW0 Q2PP12
|
| Accessions |
AAC64265 ABC40732 CAA33464 CAA77211 CAA83067 CAD57169 CCO13765 EAW96990 EAW96991 Q07954 AB209498 BAD92735 AF370375 AAQ15211 AK122840 BC021204 AAH21204 BC045107 AAH45107 BC052593 AAH52593 BC072015 AAH72015 BU502641 EF491795 EF491814 X13916 CAA32112 X55077 CAA38905 NM_002332 NP_002323
|
| Function |
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
|
| Subcellular Location |
Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
|
| Tissue Specificity |
Most abundant in liver, brain and lung.
|
| Top Pathways |
Alzheimer's disease, Malaria
|