LRP1

Gene Symbol LRP1
Entrez Gene 4035
Alt Symbol A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
Species Human
Gene Type protein-coding
Description low density lipoprotein receptor-related protein 1
Other Description LRP-1|TbetaR-V/LRP-1/IGFBP-3 receptor|alpha-2-macroglobulin receptor|apolipoprotein E receptor|prolow-density lipoprotein receptor-related protein 1|type V tgf-beta receptor
Swissprots Q8IVG8 Q07954 Q86SW0 Q2PP12
Accessions AAC64265 ABC40732 CAA33464 CAA77211 CAA83067 CAD57169 CCO13765 EAW96990 EAW96991 Q07954 AB209498 BAD92735 AF370375 AAQ15211 AK122840 BC021204 AAH21204 BC045107 AAH45107 BC052593 AAH52593 BC072015 AAH72015 BU502641 EF491795 EF491814 X13916 CAA32112 X55077 CAA38905 NM_002332 NP_002323
Function Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
Subcellular Location Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
Tissue Specificity Most abundant in liver, brain and lung.
Top Pathways Alzheimer's disease, Malaria

LRP1 CRISPR/Cas9 KO Plasmid (h) - sc-400638 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP1 HDR Plasmid (h) - sc-400638-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP1 Double Nickase Plasmid (h) - sc-400638-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP1 Double Nickase Plasmid (h2) - sc-400638-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP1 CRISPR Activation Plasmid (h) - sc-400638-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP1 CRISPR Activation Plasmid (h2) - sc-400638-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP1 Lentiviral Activation Particles (h) - sc-400638-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP1 Lentiviral Activation Particles (h2) - sc-400638-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP1 siRNA (h) - sc-40101 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRP1 shRNA Plasmid (h) - sc-40101-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRP1 shRNA (h) Lentiviral Particles - sc-40101-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU067421 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1035 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1035 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07032 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07032

LRP1 siRNA (Human) - CRH2727 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Low Density LRP RNAi - H00004035-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human LRP1 (NM_002332.2) - SHH333947 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human LRP1(NM_002332.2) - SHH160967 from Creative biogene

Category siRNA
Species Reactivities Human

Human LRP1 siRNA - orb263229 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LRP1 shRNA Plasmid (Human) - CHH2727 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LRP1 miRNA 3'UTR clone - MiUTR1H-05896 from Creative biogene

Species Reactivities Human
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