LRP1

Gene Symbol LRP1
Entrez Gene 4035
Alt Symbol A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
Species Human
Gene Type protein-coding
Description low density lipoprotein receptor-related protein 1
Other Description LRP-1|TbetaR-V/LRP-1/IGFBP-3 receptor|alpha-2-macroglobulin receptor|apolipoprotein E receptor|prolow-density lipoprotein receptor-related protein 1|type V tgf-beta receptor
Swissprots Q8IVG8 Q07954 Q86SW0 Q2PP12
Accessions AAC64265 ABC40732 CAA33464 CAA77211 CAA83067 CAD57169 CCO13765 EAW96990 EAW96991 Q07954 AB209498 BAD92735 AF370375 AAQ15211 AK122840 BC021204 AAH21204 BC045107 AAH45107 BC052593 AAH52593 BC072015 AAH72015 BU502641 EF491795 EF491814 X13916 CAA32112 X55077 CAA38905 NM_002332 NP_002323
Function Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
Subcellular Location Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
Tissue Specificity Most abundant in liver, brain and lung.
Top Pathways Alzheimer's disease, Malaria

LRP1 (A2MRα-2) - sc-19616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LRP1 (A2MRα-2) PE: sc-19616 PE. FCM analysis of human peripheral blood leukocytes.

LRP1 (A-18) - sc-16168 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LRP1 (N-20) - sc-16166 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRP1 (N-20): sc-16166. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

LRP1 (H-80) - sc-25469 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LRP1 (H-80): sc-25469. Western blot analysis of human recombinant LRP1 fusion protein.

LRP1 (8G1) - sc-57353 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

LRP1 (8B8) - sc-57352 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

LRP1 (5A6) - sc-57351 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
LRP1 (5A6): sc-57351. Indirect FCM analysis of Hep G2 cells stained with LRP1 (5A6), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>2b</sub>: sc-3879.

p-LRP1 (Tyr 4507) - sc-33049 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-LRP1 antibody - ab168454 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-LRP1 antibody (ab168454) at 1 µg/mlLane 1 : LRP1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-mouse HRP at 1/2500 dilution

Anti-LRP1 antibody - ab192308 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LRP1 antibody (ab192308)Lane 1 : HEK293T whole cell lysateLane 2 : sp2/0 whole cell lysateLane 3 : H9C2 whole cell lysate

Anti-LRP1 antibody - ab86342 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LRP1 antibody (ab86342) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-LRP1 antibody [5A6] - ab28320 from Abcam

Prices $403.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5A6
Anti-LRP1 antibody [5A6] (ab28320) at 1 µg/ml + WI38 (Human lung fibroblast cell line) Whole Cell Lysate [Non-reduced] at 25 µgSecondaryGoat polyclonal Secondary Antibody to Mouse IgG - H&L (HRP), pre-adsorbed at 1/10000 dilutiondeveloped using the ECL technique

Anti-LRP1 antibody [5A6] (Alexa Fluor® 647) - ab196710 from Abcam

Prices $425.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5A6
ab196710 staining LRP1 in HeLa cells. The cells were fixed with 100% methanol (5 min), permeabilised in 0.1% Triton X-100 for 5 minutes and then blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated with ab196710 at 1/50 dilution (shown in red) and ab195887, Mouse monoclonal [DM1A] to alpha Tubulin (Alexa Fluor® 488, shown in green) at 1/167 dilution overnight at +4°C. Nuclear DNA was labelled in blue with DAPI.Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-LRP1 antibody [8B8] - ab20753 from Abcam

Prices $392.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8B8
All lanes : Anti-LRP1 antibody [8B8] (ab20753) at 2 µg/mlLane 1 : Whole cell lysate prepared from human smooth muscle cells, untreated.Lane 2 : Whole cell lysate prepared from human smooth muscle cells, treated with 100µg/ml glycated LDL.Lysates/proteins at 30 µg per lane.SecondaryGoat Anti-Mouse IgG H&L (HRP) (ab6789) at 1/10000 dilutiondeveloped using the ECL techniqueObserved band size : 85 kDa (why is the actual band size different from the predicted?)Exposure time : 1 minuteImage courtesy of Dr Laura Toma by Abreview.See Abreview

Anti-LRP1 antibody [8G1] - ab20384 from Abcam

Prices $390.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 8G1
ab20384 staining human mesothelial cells by flow cytometry.  Cells were lifted in lifting buffer plus FBS and fixed with formaldehyde.  The cell population was gated against mIgG control.  The primary antibody was diluted 1/100 in 0.2% BSA in PBS and incubated with the sample at a concentration of 1 µg/100 µl for 1 hour at 4°C.  A FITC conjugated goat anti-mouse antibody was used as the secondary, diluted 1/100 and incubated with the sample at a concentration of 1 µg/100 µl.See Abreview

Anti-LRP1 antibody [EPR3724] - ab92544 from Abcam

Prices $404.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3724
All lanes : Anti-LRP1 antibody [EPR3724] (ab92544) at 1/50000 dilution (purified)Lane 1 : A549 cell lysateLane 2 : Human fetal brain tissue lysateLysates/proteins at 20 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-LRP1 antibody [EPR3724] (Alexa Fluor® 488) - ab195567 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3724
ab195567 staining LRP1 in differentiated Neuro2a cells. The cells were fixed with 100% methanol (5 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1%PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab195567 at a 1/100 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at a 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in differentiated Neuro2a cells fixed with 4% formaldehyde (10 min).

Anti-LRP1 / CD91 Antibody - LS-C143996 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-LRP1 / CD91 Antibody (clone 5A6, Biotin) - LS-C150856 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5A6

Anti-LRP1 / CD91 Antibody (phospho-Ser4520) - LS-C96895 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-LRP1 / CD91 Antibody (aa4486-4535) - LS-C118336 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HepG2 cells, using CD91 (Ab-4520) Antibody. The lane on the right is treated with the synthesized peptide.

Anti-LRP1 / CD91 Antibody (aa211-260) - LS-C102800 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LRP1 / CD91 antibody LS-C102800 Western blot of 721_B cell lysate.

Anti-LRP1 / CD91 Antibody (aa211-260) - LS-C112215 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LRP1 / CD91 antibody LS-C112215 Western blot of 293T cell lysate.

Anti-LRP1 / CD91 Antibody (clone 8G1, Biotin) - LS-C150860 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8G1

Anti-LRP1 / CD91 Antibody (clone 5A6, FITC) - LS-C150857 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5A6
Search more