LRP1
| Gene Symbol | LRP1 |
|---|---|
| Entrez Gene | 4035 |
| Alt Symbol | A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | low density lipoprotein receptor-related protein 1 |
| Other Description | LRP-1|TbetaR-V/LRP-1/IGFBP-3 receptor|alpha-2-macroglobulin receptor|apolipoprotein E receptor|prolow-density lipoprotein receptor-related protein 1|type V tgf-beta receptor |
| Swissprots | Q8IVG8 Q07954 Q86SW0 Q2PP12 |
| Accessions | AAC64265 ABC40732 CAA33464 CAA77211 CAA83067 CAD57169 CCO13765 EAW96990 EAW96991 Q07954 AB209498 BAD92735 AF370375 AAQ15211 AK122840 BC021204 AAH21204 BC045107 AAH45107 BC052593 AAH52593 BC072015 AAH72015 BU502641 EF491795 EF491814 X13916 CAA32112 X55077 CAA38905 NM_002332 NP_002323 |
| Function | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. |
| Subcellular Location | Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. |
| Tissue Specificity | Most abundant in liver, brain and lung. |
| Top Pathways | Alzheimer's disease, Malaria |
Human LRP1 full length protein - ab158828 from Abcam
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Phospho-LPR1S4520-Antibody-Blocking-peptide - BP3143a from Abgent, a WuXi AppTec company
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Lipoproteins, Intermediate density protein - GTX65502 from GeneTex
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Recombinant Human LRP-1 Cluster II Fc Chimera, CF - 2368-L2-050 from R&D Systems
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Recombinant Human LRP-1 Cluster IV Fc Chimera, CF - 5395-L4-050 from R&D Systems
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Recombinant Human LRP-1 Cluster III Fc Chimera, CF - 4824-L3-050 from R&D Systems
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CD91 Blocking Peptide - abx062890 from Abbexa
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Human LRP1 Protein - abx067817 from Abbexa
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CD91 / LRP1 - H00004035-G01 from Acris Antibodies
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CD91 / LRP1 - H00004035-P01-10 from Acris Antibodies
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CD91 / LRP1 - H00004035-P01-25 from Acris Antibodies
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Low Density Lipoprotein Receptor Related Protein - 20-7380 from ARP American Research Products
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LRP1 fusion protein - ag13853 from Proteintech Group
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Recombinant Human LRP1 protein, Fc-tagged - LRP1-652H from Creative Biomart
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Recombinant Human LRP1 protein, Fc-tagged - LRP1-653H from Creative Biomart
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Recombinant Human LRP1 protein, Fc-tagged - LRP1-654H from Creative Biomart
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Recombinant Human LRP1, None tagged - LRP1-3357H from Creative Biomart
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Native Human Intermediate Density Lipoproteins Protein - LRP1-18H from Creative Biomart
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Native Human Lipoproteins - LRP1-87H from Creative Biomart
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Recombinant Low Density Lipoprotein Receptor Related Protein 1 (LRP1) - RPB010Hu01 from Uscn Life Science Inc.
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Recombinant Low Density Lipoprotein Receptor Related Protein 1 (LRP1) - RPB010Mu01 from Uscn Life Science Inc.
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Recombinant Low Density Lipoprotein Receptor Related Protein 1 (LRP1) - RPB010Mu02 from Uscn Life Science Inc.
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Human LRP1 / A2MR / CD91 Protein (aa 786-1165) - 11665-HCCH-50 from Sino Biological
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CD91 Blocking Peptide - CBP1696 from Cohesion Biosciences
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LRP1 (G4514) Peptide - BS3761P from Bioworld Technology
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