| Gene Symbol | STOML2 |
|---|---|
| Entrez Gene | 30968 |
| Alt Symbol | HSPC108, SLP-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | stomatin (EPB72)-like 2 |
| Other Description | EPB72-like protein 2|paraprotein target 7|paratarg-7|stomatin-like 2|stomatin-like protein 2, mitochondrial |
| Swissprots | Q9P042 B4E1K7 Q9UJZ1 Q96FY2 D3DRN3 Q53G29 O60376 |
| Accessions | AAC07983 CAG30023 CAH05402 EAW58394 EAW58395 EAW58396 Q9UJZ1 AA657517 AF161458 AAF29073 AF190167 AAF09142 AF282596 AAF91466 AK027405 BAB55091 AK130546 BAC85377 AK223102 BAD96822 AK225114 AK303883 BAG64819 AK307343 AK308552 AW273545 BC002442 AAH02442 BC003025 AAH03025 BC010152 AAH10152 BC014990 AAH14990 BQ935988 BU528995 BX400542 DQ892677 ABM83603 DQ895920 ABM86846 HY039403 HY367065 NM_001287031 NP_001273960 NM_001287032 NP_001273961 NM_001287033 NP_001273962 NM_013442 NP_038470 |
| Function | Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. {ECO |
| Subcellular Location | Mitochondrion inner membrane. Mitochondrion intermembrane space. Cell membrane; Peripheral membrane protein. Membrane raft; Peripheral membrane protein. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells. |
| Tissue Specificity | Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level). {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:11435687, ECO:0000269|PubMed:18641330}. |