| Gene Symbol |
DENR
|
| Entrez Gene |
8562
|
| Alt Symbol |
DRP, DRP1, SMAP-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
density-regulated protein
|
| Other Description |
smooth muscle cell associated protein-3|smooth muscle cell-associated protein 3
|
| Swissprots |
O43583 Q9H3U6 Q9UKZ0
|
| Accessions |
EAW98338 EAW98339 EAW98340 EAW98341 EAW98342 EAW98343 O43583 AB014731 BAB20268 AF038554 AAC02985 AF103800 AAF02420 AI093093 AI093455 AK299463 BAG61429 BC000925 BC007860 AAH07860 BG705827 BI871385 BP872988 CB043904 CN300034 HQ447117 ADQ31604 NM_003677 NP_003668
|
| Function |
May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. {ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:17878526, ECO:0000269|PubMed:20713520}.
|
| Tissue Specificity |
Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney. {ECO:0000269|PubMed:9628587}.
|
![Western Blot: DENR Overexpression Lysate (Adult Normal) [NBL1-09832] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DENR.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9196_DENR%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09832-img0002.jpg)