| Gene Symbol |
PTBP2
|
| Entrez Gene |
58155
|
| Alt Symbol |
PTBLP, brPTB, nPTB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polypyrimidine tract binding protein 2
|
| Other Description |
PTB-like protein|neural polypyrimidine tract binding protein|neurally-enriched homolog of PTB|polypyrimidine tract-binding protein 2
|
| Swissprots |
Q969N9 Q9UKA9 Q96Q76 Q8NFB1 Q8N160 Q8NFB0 Q8N0Z1
|
| Accessions |
AAD09652 EAW73005 EAW73006 EAW73007 EAW73008 EAW73009 EAW73010 Q9UKA9 AB051232 BAB71742 AB051233 BAB71743 AB209266 BAD92503 AF176085 AAF14284 AF530580 AAM94624 AF530581 AAM94625 AF530582 AAM94626 AF530583 AAM94627 AF530584 AAM94628 AF530585 AAM94629 AI052528 AI968454 AK022716 AK025333 AK092216 AK295384 BAG58340 AK299755 BAG61644 AK299897 BAG61740 AK299922 BAG61757 BC016582 AAH16582 BK000526 DAA00060 BP250235 DB473562 DQ891027 ABM81953 EU176551 ABW03352 XM_011541874 XP_011540176 XM_011541875 XP_011540177 XM_011541876 XP_011540178 XR_946720 XR_946721 XR_946722 XR_946723 NM_001300985 NP_001287914 NM_001300986 NP_001287915 NM_001300987 NP_001287916 NM_001300988 NP_001287917 NM_001300989 NP_001287918 NM_001300990 NP_001287919 NM_021190 NP_067013 NR_125356 NR_125357
|
| Function |
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:12667457}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non- neuronal tissues. {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:12213192}.
|