PTBP2

Gene Symbol PTBP2
Entrez Gene 58155
Alt Symbol PTBLP, brPTB, nPTB
Species Human
Gene Type protein-coding
Description polypyrimidine tract binding protein 2
Other Description PTB-like protein|neural polypyrimidine tract binding protein|neurally-enriched homolog of PTB|polypyrimidine tract-binding protein 2
Swissprots Q969N9 Q9UKA9 Q96Q76 Q8NFB1 Q8N160 Q8NFB0 Q8N0Z1
Accessions AAD09652 EAW73005 EAW73006 EAW73007 EAW73008 EAW73009 EAW73010 Q9UKA9 AB051232 BAB71742 AB051233 BAB71743 AB209266 BAD92503 AF176085 AAF14284 AF530580 AAM94624 AF530581 AAM94625 AF530582 AAM94626 AF530583 AAM94627 AF530584 AAM94628 AF530585 AAM94629 AI052528 AI968454 AK022716 AK025333 AK092216 AK295384 BAG58340 AK299755 BAG61644 AK299897 BAG61740 AK299922 BAG61757 BC016582 AAH16582 BK000526 DAA00060 BP250235 DB473562 DQ891027 ABM81953 EU176551 ABW03352 XM_011541874 XP_011540176 XM_011541875 XP_011540177 XM_011541876 XP_011540178 XR_946720 XR_946721 XR_946722 XR_946723 NM_001300985 NP_001287914 NM_001300986 NP_001287915 NM_001300987 NP_001287916 NM_001300988 NP_001287917 NM_001300989 NP_001287918 NM_001300990 NP_001287919 NM_021190 NP_067013 NR_125356 NR_125357
Function RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:12667457}.
Subcellular Location Nucleus {ECO:0000250}.
Tissue Specificity Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non- neuronal tissues. {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:12213192}.

PTBP-2 CRISPR/Cas9 KO Plasmid (h) - sc-404312 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTBP-2 HDR Plasmid (h) - sc-404312-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTBP-2 Double Nickase Plasmid (h) - sc-404312-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTBP-2 Double Nickase Plasmid (h2) - sc-404312-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTBP-2 CRISPR Activation Plasmid (h) - sc-404312-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTBP-2 CRISPR Activation Plasmid (h2) - sc-404312-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTBP-2 Lentiviral Activation Particles (h) - sc-404312-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTBP-2 Lentiviral Activation Particles (h2) - sc-404312-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTBP-2 siRNA (h) - sc-78824 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PTBP-2 shRNA Plasmid (h) - sc-78824-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PTBP-2 shRNA (h) Lentiviral Particles - sc-78824-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PTBP2 RNAi - H00058155-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU091671 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17650 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17650 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PTBP2 siRNA (Human) - CRJ1700 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PTBP2 (NM_021190.2) - SHH385772 from Creative biogene

Category siRNA
Species Reactivities Human

Human PTBP2 siRNA - orb272201 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PTBP2 shRNA Plasmid (Human) - CHJ1700 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PTBP2 miRNA 3'UTR clone - MiUTR3H-10011 from Creative biogene

Species Reactivities Human
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