GREM1

Gene Symbol GREM1
Entrez Gene 26585
Alt Symbol C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, GREMLIN, HMPS, HMPS1, IHG-2, MPSH, PIG2
Species Human
Gene Type protein-coding
Description gremlin 1, DAN family BMP antagonist
Other Description DAN domain family member 2|cell proliferation-inducing gene 2 protein|colorectal adenoma and carcinoma 1|cysteine knot superfamily 1, BMP antagonist 1|down-regulated in Mos-transformed cells protein|gremlin 1, cysteine knot superfamily, homolog|gremlin 1-like protein|gremlin-1|increased in high glucose-2
Swissprots Q8N914 Q52LV3 O60565 Q8N936
Accessions AAZ29612 BAA84462 CCQ77676 EAW92267 EAW92268 EAW92269 O60565 AF045800 AAC39725 AF110137 AAF06677 AF154054 AAG23891 AK095741 AK095890 BAC04643 AK095972 BAG53181 AK312265 BAG35196 AL359059 AL359060 AY232290 AAP69985 BC069525 AAH69525 BC093778 AAH93778 BC101611 AAI01612 HQ448400 ADQ32880 W19275 XM_005254301 XP_005254358 XM_006725542 XP_006725605 XM_011548909 XP_011547211 NM_001191322 NP_001178251 NM_001191323 NP_001178252 NM_013372 NP_037504
Function Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity). {ECO:0000250}.
Subcellular Location Secreted {ECO:0000305}.
Tissue Specificity Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts. {ECO:0000269|PubMed:10894942, ECO:0000269|PubMed:22561515}.

Gremlin Antibody - 4383 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western analysis of cell extracts from COS cells, untreated or transfected with a mouse Gremlin expression construct, using Gremlin Antibody.

gremlin (FL-184) - sc-28873 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
gremlin (FL-184): sc-28873. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis cancer tissue showing cytoplasmic staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

gremlin (C-19) - sc-18276 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

gremlin (P-19) - sc-18275 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

gremlin-1 (N-20) - sc-18274 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
gremlin-1 (N-20): sc-18274. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing cytoplasmic staining of glandular cells.

Anti-Gremlin 1 antibody - ab189267 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human small intestine tissue, labeling Gremlin 1 using ab189267 at 10 µg/ml, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-Gremlin 1 antibody - ab57139 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57139 Gremlin 1 antibody at 1ug/ml.

Anti-Gremlin 1 antibody - ab157576 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Gremlin 1 antibody (ab157576) at 1 µg/ml + rat testis lysate at 10 µg

Anti-Gremlin 1 antibody - ab22138 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of CKTSF1B1 in human colon cancer tissue using Ab22138.

Anti-Gremlin 1 antibody - C-terminal - ab140010 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Gremlin 1 antibody - C-terminal (ab140010) at 1 µg/ml + Mouse Testis lysates at 10 µg

Anti-GREM1 / Gremlin-1 Antibody (aa162-176) IHC-plus™ - LS-B810 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Gremlin-1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B810 concentration 10 ug/ml.

Anti-GREM1 / Gremlin-1 Antibody (aa147-175) - LS-C100381 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ISH and IMH demonstrating gremlin mRNA and gremlin protein in crescentic PECs and tubular epithelial cells of patients with pauci-immune crescentic GN. In comparison with normal renal tissue in which there is no expression of gremlin mRNA (C), proliferating PECs of glomerular crescents show a strong expression of gremlin mRNA by ISH (A); and gremlin protein expression by IMH (B); immune competent infiltrating interstitial cells are also strongly positive for gremlin staining (E); and CTGF was also expressed in these glomerular crescentic cells (F).

Anti-GREM1 / Gremlin-1 Antibody (C-Terminus) - LS-C121626 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GREM1 / Gremlin-1 Antibody (aa110-139, AP) - LS-C259593 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GREM1 / Gremlin-1 Antibody (clone 4C2) - LS-C125371 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C2

Anti-GREM1 / Gremlin-1 Antibody (aa110-139, APC) - LS-C259594 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GREM1 / Gremlin-1 Antibody (aa110-139, Biotin) - LS-C259595 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GREM1 / Gremlin-1 Antibody (aa110-139, FITC) - LS-C259596 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GREM1 / Gremlin-1 Antibody (aa110-139, PE) - LS-C259598 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GREM1 / Gremlin-1 Antibody (aa110-139, Azide-free, HRP) - LS-C259597 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GREM1 / Gremlin-1 Antibody - LS-C658 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of CKTSF1B1 in human colon cancer tissue using antibody.

Anti-GREM1 / Gremlin-1 Antibody (aa154-184, AP) - LS-C259599 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GREM1 / Gremlin-1 Antibody (aa154-184, APC) - LS-C259600 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GREM1 / Gremlin-1 Antibody (aa154-184, FITC) - LS-C259601 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GREM1 / Gremlin-1 Antibody (aa154-184, Biotin) - LS-C259602 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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