GREM1

Gene Symbol	GREM1
Entrez Gene	26585
Alt Symbol	C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, GREMLIN, HMPS, HMPS1, IHG-2, MPSH, PIG2
Species	Human
Gene Type	protein-coding
Description	gremlin 1, DAN family BMP antagonist
Other Description	DAN domain family member 2|cell proliferation-inducing gene 2 protein|colorectal adenoma and carcinoma 1|cysteine knot superfamily 1, BMP antagonist 1|down-regulated in Mos-transformed cells protein|gremlin 1, cysteine knot superfamily, homolog|gremlin 1-like protein|gremlin-1|increased in high glucose-2
Swissprots	Q8N914 Q52LV3 O60565 Q8N936
Accessions	AAZ29612 BAA84462 CCQ77676 EAW92267 EAW92268 EAW92269 O60565 AF045800 AAC39725 AF110137 AAF06677 AF154054 AAG23891 AK095741 AK095890 BAC04643 AK095972 BAG53181 AK312265 BAG35196 AL359059 AL359060 AY232290 AAP69985 BC069525 AAH69525 BC093778 AAH93778 BC101611 AAI01612 HQ448400 ADQ32880 W19275 XM_005254301 XP_005254358 XM_006725542 XP_006725605 XM_011548909 XP_011547211 NM_001191322 NP_001178251 NM_001191323 NP_001178252 NM_013372 NP_037504
Function	Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000305}.
Tissue Specificity	Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts. {ECO:0000269|PubMed:10894942, ECO:0000269|PubMed:22561515}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GREM1 / Gremlin-1 ELISA Kit (Sandwich ELISA) - LS-F6538 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 125 pg/ml Range 0.819-80 ng/ml

Mouse GREM1 / Gremlin-1 ELISA Kit (Sandwich ELISA) - LS-F7413 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 0.819-80 ng/ml

Mouse Gremlin DuoSet ELISA - DY956 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 93.80 - 6,000 pg/mL

Gremlin 1, GREM1, Human, ELISA Kit - E-EL-H1350 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Gremlin 1 (GREM1), Human, ELISA Kit - SEC128Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.064ng/mL Range 0.156-10ng/mL

Gremlin-1 (GREM1), Human, ELISA Kit - CSB-EL009892HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Gremlin-1, GREM1, Human, ELISA Kit - E2130h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.125-8 ng/mL

GremLin 1, GREM1, Mouse, ELISA Kit - E-EL-M0595 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 46.875 Range 78.125-5000pg/mL

GremLin 1, GREM1, Rat, ELISA Kit - E-EL-R0457 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Gremlin 1, GREM1, Rabbit, ELISA Kit - E-EL-RB1763 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Gremlin 1, GREM1, Chicken, ELISA Kit - E-EL-Ch0069 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Gremlin 1, GREM1, Porcine, ELISA Kit - E-EL-P1144 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Gremlin 1, GREM1, Guinea Pig, ELISA Kit - E-EL-GP0878 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Gremlin 1, GREM1, Monkey, ELISA Kit - E-EL-MK1682 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human GREM1 ELISA Kit - HG0260 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine GREM1 ELISA Kit - AG0260 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

GREM1, ELISA Kit - MBS2504378 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.875pg/mL Range 78.125--5000pg/mL

GREM1, ELISA Kit - MBS2505200 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

Gremlin 1, ELISA Kit - MBS011520 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gremlin 1, ELISA Kit - MBS724762 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gremlin 1, ELISA Kit - MBS005658 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gremlin 1, ELISA Kit - MBS067875 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gremlin 1, ELISA Kit - MBS034097 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gremlin 1, ELISA Kit - MBS007989 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gremlin 1, ELISA Kit - MBS028996 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.25 ng/ml - 8 ng/ml.

Search more