GREM1

Gene Symbol	GREM1
Entrez Gene	26585
Alt Symbol	C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, GREMLIN, HMPS, HMPS1, IHG-2, MPSH, PIG2
Species	Human
Gene Type	protein-coding
Description	gremlin 1, DAN family BMP antagonist
Other Description	DAN domain family member 2|cell proliferation-inducing gene 2 protein|colorectal adenoma and carcinoma 1|cysteine knot superfamily 1, BMP antagonist 1|down-regulated in Mos-transformed cells protein|gremlin 1, cysteine knot superfamily, homolog|gremlin 1-like protein|gremlin-1|increased in high glucose-2
Swissprots	Q8N914 Q52LV3 O60565 Q8N936
Accessions	AAZ29612 BAA84462 CCQ77676 EAW92267 EAW92268 EAW92269 O60565 AF045800 AAC39725 AF110137 AAF06677 AF154054 AAG23891 AK095741 AK095890 BAC04643 AK095972 BAG53181 AK312265 BAG35196 AL359059 AL359060 AY232290 AAP69985 BC069525 AAH69525 BC093778 AAH93778 BC101611 AAI01612 HQ448400 ADQ32880 W19275 XM_005254301 XP_005254358 XM_006725542 XP_006725605 XM_011548909 XP_011547211 NM_001191322 NP_001178251 NM_001191323 NP_001178252 NM_013372 NP_037504
Function	Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000305}.
Tissue Specificity	Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts. {ECO:0000269|PubMed:10894942, ECO:0000269|PubMed:22561515}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Gremlin 1 full length protein - ab139770 from Abcam Category Protein Prices $192.00, $316.00 Sizes 10 µg, 50 µg Source CHO Species Human

Human Gremlin 1 full length protein - ab140048 from Abcam Category Protein Source E. coli Species Human

Human Gremlin 1 peptide - ab69732 from Abcam Category Peptide

Human Gremlin 1 protein fragment - ab112406 from Abcam Category Protein Source Wheat germ Species Human

Human Gremlin 1 protein fragment - ab111462 from Abcam Category Protein Source E. coli Species Human

GREM1 / Gremlin-1 Antibody Blocking Peptide - LS-E1521 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GREM1 / Gremlin-1 Antibody Blocking Peptide - LS-E8088 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GREM1 / Gremlin-1 Antibody Blocking Peptide - LS-E21044 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GREM1 / Gremlin-1 Antibody Blocking Peptide - LS-E15596 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Gremlin 1 Protein - H00026585-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

Gremlin 1 Partial Recombinant Protein - H00026585-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Gremlin 1 Protein - NBP2-23088 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Gremlin 1 Peptide - P1741 from Novus Biologicals Category Peptide Species Human

GREM1-Antibody-C-term-Blocking-peptide - BP12247b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Gremlin 1 recombinant protein - GTX53832 from GeneTex Category Protein Prices $199.00 Sizes 50 μg Source CHO cells

Recombinant Human Gremlin, CF - 5190-GR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Lys25-Asp184, with a C-terminal 10-His tag

Human Gremlin 1 protein - orb191138 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

GREM1 protein (His tag) - 80R-2665 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Human Gremlin 1 Protein - abx066922 from Abbexa Category Protein Source E.coli Species Human

Gremlin-1 / GREM1 - AR26007PU-N from Acris Antibodies Category Protein Prices $255.00 Sizes 50 µg Source E. coli Species Human

Gremlin-1 / GREM1 - AR31096PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 50 µg Source CHO cells Species Human

Gremlin-1 / GREM1 - AR31096PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 10 µg Source CHO cells Species Human

Gremlin-1 / GREM1 - AR31150PU-N from Acris Antibodies Category Protein Prices $255.00 Sizes 25 µg Source E. coli Species Human

Gremlin-1 / GREM1 (25-184, His-tag) - AR50785PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Gremlin-1 / GREM1 (25-184, His-tag) - AR50785PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

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