| Gene Symbol |
SLC51A
|
| Entrez Gene |
200931
|
| Alt Symbol |
OSTA, OSTalpha
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 51, alpha subunit
|
| Other Description |
OST-alpha|organic solute transporter alpha|organic solute transporter subunit alpha|organic solute transporter, alpha subunit|solute carrier family 51 subunit alpha
|
| Swissprots |
Q86UW1 Q6ZMC7
|
| Accessions |
EAW53665 Q86UW1 AK172837 BAD18802 AK300996 BAG62615 AK310276 AY194243 AAP23993 BC029606 AAH29606 NM_152672 NP_689885
|
| Function |
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. {ECO:0000269|PubMed:16317684}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}.
|
| Top Pathways |
Bile secretion
|
![Western Blot: OSTalpha Overexpression Lysate (Adult Normal) [NBP2-04427] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OSTalpha.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/23033_OSTalpha%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-04427-img0001.jpg)