PLA2G4A

Gene Symbol PLA2G4A
Entrez Gene 5321
Alt Symbol PLA2G4, cPLA2-alpha
Species Human
Gene Type protein-coding
Description phospholipase A2, group IVA (cytosolic, calcium-dependent)
Other Description cPLA2|calcium-dependent phospholipid-binding protein|cytosolic phospholipase A2|lysophospholipase|phosphatidylcholine 2-acylhydrolase|phospholipase A2 group IVA
Swissprots Q29R80 B1AKG4 P47712
Accessions AAS45712 AHF45879 BAA07375 EAW91217 EAW91218 P47712 AK290336 BAF83025 AK302938 BAG64096 BC114340 AAI14341 BX118890 DA451491 M68874 AAA60105 M72393 AAB00789 XM_005245267 XP_005245324 XM_011509641 XP_011507943 XM_011509642 XP_011507944 XM_011509643 XP_011507945 XR_921838 NM_024420 NP_077734
Function Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Subcellular Location Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.
Tissue Specificity Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
Top Pathways Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, VEGF signaling pathway, Inflammatory mediator regulation of TRP channels

Phospho-cPLA2 (Ser505) Antibody - 2831 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or TNF-α-treated (10 ng/ml for 15 minutes), and NIH/3T3 and COS cells, using Phospho-cPLA2 (Ser505) Antibody (upper) or cPLA2 Antibody #2832 (lower).

cPLA2 (D11H4) Rabbit mAb - 5479 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D11H4
Western blot analysis of extracts from various cell lines using cPLA2 (D11H4) Rabbit mAb.

cPLA2 Antibody - 2832 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or TNF-α-treated (10 ng/ml for 15 minutes), and NIH/3T3 and COS cells, using Phospho-cPLA2 (Ser505) Antibody #2831 (upper) or cPLA2 Antibody (lower).

cPLA2 (D49A7) Rabbit mAb - 5249 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D49A7
Western blot analysis of extracts from various cell lines using cPLA2 (D49A7) Rabbit mAb.

cPLA 2 (H-12) - sc-376636 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cPLA<sub>2</sub> (H-12): sc-376636. Western blot analysis of cPLA<sub>2</sub> expression in non-transfected 293T: sc-117752 (A), mouse cPLA<sub>2</sub> transfected 293T: sc-119430 (B), HeLa (C) and NIH/3T3 (D) whole cell lysates.

cPLA 2 (N-216) - sc-438 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cPLA<sub>2</sub> (N-216): sc-438. Western blot analysis of cPLA<sub>2</sub> expression in NIH/3T3 whole cell lysate.

cPLA 2 (E-1) - sc-376618 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cPLA<sub>2</sub> (E-1): sc-376618. Western blot analysis of cPLA<sub>2</sub> expression in NIH/3T3 (A) and HeLa (B) whole cell lysates.

cPLA 2 (E-3) - sc-137069 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cPLA<sub>2</sub> (E-3): sc-137069. Western blot analysis of cPLA<sub>2</sub> expression in non-transfected 293T: sc-117752 (A), mouse cPLA<sub>2</sub> transfected 293T: sc-119430 (B), HeLa (C) and NIH/3T3 (D) whole cell lysates.

cPLA 2 (4-4B-3C) - sc-454 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cPLA<sub>2</sub> (4-4B-3C): sc-454. Western blot analysis of cPLA<sub>2</sub> expression in HeLa (A) and NIH/3T3 (B) whole cell lysates.

cPLA 2 (C-20) - sc-1724 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cPLA<sub>2</sub> (C-20): sc-1724. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.

p-cPLA 2 (Ser 505) - sc-34391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p-cPLA<sub>2</sub> (Ser 505): sc-34391. Western blot analysis of cPLA<sub>2</sub> phosphorylation in non-transfected: sc-117752 (A) and mouse cPLA<sub>2</sub> transfected: sc-119430 (B) 293T whole cell lysates.

Anti-PLA2G4A Antibody (aa563-749) - LS-C314247 from LifeSpan Bioscience

Prices $405.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Western blot of recombinant PLA2G4A.

Anti-PLA2G4A Antibody (aa686-700) - LS-C313173 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of PLA2G4 / PLA2G4A antibody. Lane 1: Rat Testis Tissue Lysate. Lane 2: Rat Brain Tissue Lysate. Lane 3: A549 Cell Lysate. Lane 4: COLO320 Cell Lysate..

Anti-PLA2G4A Antibody (aa153-166) IHC-plus™ - LS-B5952 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-PLA2G4A antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5952 concentration 3.75 ug/ml.

Anti-PLA2G4A Antibody (aa513-541) - LS-C163759 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma with PLA2G4A Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-PLA2G4A Antibody (phospho-Ser505) - LS-C3262 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLA2G4A Antibody (phospho-Ser505) - LS-C17275 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G4A Antibody (APC) - LS-C226137 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G4A Antibody (AP) - LS-C226138 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G4A Antibody (Azide-free, HRP) - LS-C226140 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G4A Antibody (FITC) - LS-C226139 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G4A Antibody (PE) - LS-C226141 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G4A Antibody (Biotin) - LS-C227146 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G4A Antibody (Internal) - LS-C330585 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G4A Antibody (clone 10G5) - LS-C197915 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 10G5
Detection limit for recombinant GST tagged PLA2G4A is approximately 0.3 ng/ml as a capture antibody.
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