| Gene Symbol |
PLA2G4A
|
| Entrez Gene |
5321
|
| Alt Symbol |
PLA2G4, cPLA2-alpha
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A2, group IVA (cytosolic, calcium-dependent)
|
| Other Description |
cPLA2|calcium-dependent phospholipid-binding protein|cytosolic phospholipase A2|lysophospholipase|phosphatidylcholine 2-acylhydrolase|phospholipase A2 group IVA
|
| Swissprots |
Q29R80 B1AKG4 P47712
|
| Accessions |
AAS45712 AHF45879 BAA07375 EAW91217 EAW91218 P47712 AK290336 BAF83025 AK302938 BAG64096 BC114340 AAI14341 BX118890 DA451491 M68874 AAA60105 M72393 AAB00789 XM_005245267 XP_005245324 XM_011509641 XP_011507943 XM_011509642 XP_011507944 XM_011509643 XP_011507945 XR_921838 NM_024420 NP_077734
|
| Function |
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
|
| Subcellular Location |
Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.
|
| Tissue Specificity |
Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
|
| Top Pathways |
Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, VEGF signaling pathway, Inflammatory mediator regulation of TRP channels
|
![Western Blot: Phospholipase A2, group IVA Overexpression Lysate (Adult Normal) [NBL1-14474] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Phospholipase A2, group IVA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11981_Phospholipase%2520A2-%2520group%2520IVA%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14474-img0002.jpg)