Gene Symbol | PLA2G4A |
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Entrez Gene | 5321 |
Alt Symbol | PLA2G4, cPLA2-alpha |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase A2, group IVA (cytosolic, calcium-dependent) |
Other Description | cPLA2|calcium-dependent phospholipid-binding protein|cytosolic phospholipase A2|lysophospholipase|phosphatidylcholine 2-acylhydrolase|phospholipase A2 group IVA |
Swissprots | Q29R80 B1AKG4 P47712 |
Accessions | AAS45712 AHF45879 BAA07375 EAW91217 EAW91218 P47712 AK290336 BAF83025 AK302938 BAG64096 BC114340 AAI14341 BX118890 DA451491 M68874 AAA60105 M72393 AAB00789 XM_005245267 XP_005245324 XM_011509641 XP_011507943 XM_011509642 XP_011507944 XM_011509643 XP_011507945 XR_921838 NM_024420 NP_077734 |
Function | Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. |
Subcellular Location | Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion. |
Tissue Specificity | Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. |
Top Pathways | Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, VEGF signaling pathway, Inflammatory mediator regulation of TRP channels |
Active human Phospholipase A2 full length protein - ab198469 from Abcam
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Human Phospholipase A2 peptide - ab86259 from Abcam
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Human Phospholipase A2 protein fragment - ab112338 from Abcam
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PLA2G4A Antibody Blocking Peptide - LS-E27392 from LifeSpan Bioscience
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PLA2G4A Antibody Blocking Peptide - LS-E9609 from LifeSpan Bioscience
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Recombinant Human PLA2G4A Protein - H00005321-Q01 from Novus Biologicals
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PLA2G4A-Antibody-Center-Blocking-Peptide - BP8510c from Abgent, a WuXi AppTec company
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PLA2G4A blocking peptide - GTX88072-PEP from GeneTex
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Recombinant Human PLA2G4A, CF - 6659-PL-010 from R&D Systems
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PLA2G4A peptide - orb219151 from Biorbyt
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Human cPLA2 Protein - abx068536 from Abbexa
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Human cPLA2 Protein - abx068535 from Abbexa
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PLA2G4A (phospho-Ser505) Blocking Peptide - abx062181 from Abbexa
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PLA2G4A Blocking Peptide - abx062182 from Abbexa
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PLA2G4A Blocking Peptide - abx062183 from Abbexa
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Phospholipase A2 Peptide - AC21-2216-P from Abcore
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PLA2G4A - H00005321-Q01-10 from Acris Antibodies
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PLA2G4A - H00005321-Q01-25 from Acris Antibodies
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Phospholipase A2, Cytosolic (cPLA2), Human - 20-7868 from ARP American Research Products
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Phospholipase A2, Cytosolic (cPLA2), Human - 20-7869 from ARP American Research Products
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PLA2G4A Peptide - 42-609P from ProSci
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PLA2G4A fusion protein - ag15202 from Proteintech Group
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Recombinant Human PLA2G4A, His-tagged - PLA2G4A-557H from Creative Biomart
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Recombinant Human PLA2G4A - PLA2G4A-30736TH from Creative Biomart
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Recombinant Human PLA2G4A, GST-tagged - PLA2G4A-1752H from Creative Biomart
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