| Gene Symbol | PLA2G4A |
|---|---|
| Entrez Gene | 5321 |
| Alt Symbol | PLA2G4, cPLA2-alpha |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipase A2, group IVA (cytosolic, calcium-dependent) |
| Other Description | cPLA2|calcium-dependent phospholipid-binding protein|cytosolic phospholipase A2|lysophospholipase|phosphatidylcholine 2-acylhydrolase|phospholipase A2 group IVA |
| Swissprots | Q29R80 B1AKG4 P47712 |
| Accessions | AAS45712 AHF45879 BAA07375 EAW91217 EAW91218 P47712 AK290336 BAF83025 AK302938 BAG64096 BC114340 AAI14341 BX118890 DA451491 M68874 AAA60105 M72393 AAB00789 XM_005245267 XP_005245324 XM_011509641 XP_011507943 XM_011509642 XP_011507944 XM_011509643 XP_011507945 XR_921838 NM_024420 NP_077734 |
| Function | Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. |
| Subcellular Location | Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion. |
| Tissue Specificity | Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. |
| Top Pathways | Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, VEGF signaling pathway, Inflammatory mediator regulation of TRP channels |