| Gene Symbol |
EDAR
|
| Entrez Gene |
10913
|
| Alt Symbol |
DL, ECTD10A, ECTD10B, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, HRM1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ectodysplasin A receptor
|
| Other Description |
EDA-A1 receptor|anhidrotic ectodysplasin receptor 1|downless homolog|downless, mouse, homolog of|ectodermal dysplasia receptor|ectodysplasin 1, anhidrotic receptor|ectodysplasin-A receptor|tumor necrosis factor receptor superfamily member EDAR
|
| Swissprots |
Q9UNE0 B4DLC5 Q9UND9 E9PC98 B2R9H2 Q52LL5 D3DX74
|
| Accessions |
AAD50077 EAW53868 EAW53869 Q9UNE0 AF130988 AAD50076 AI017384 AK296936 BAG59487 AK313781 BAG36519 BC093870 AAH93870 BC093872 AAH93872 CR749352 CAH18205 EU832142 ACE87492 EU832235 ACE86805 XM_006712204 XP_006712267 XM_011510502 XP_011508804 XM_011510503 XP_011508805 XM_011510504 XP_011508806 NM_022336 NP_071731
|
| Function |
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines.
|
| Top Pathways |
Cytokine-cytokine receptor interaction
|