Gene Symbol | EDAR |
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Entrez Gene | 10913 |
Alt Symbol | DL, ECTD10A, ECTD10B, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, HRM1 |
Species | Human |
Gene Type | protein-coding |
Description | ectodysplasin A receptor |
Other Description | EDA-A1 receptor|anhidrotic ectodysplasin receptor 1|downless homolog|downless, mouse, homolog of|ectodermal dysplasia receptor|ectodysplasin 1, anhidrotic receptor|ectodysplasin-A receptor|tumor necrosis factor receptor superfamily member EDAR |
Swissprots | Q9UNE0 B4DLC5 Q9UND9 E9PC98 B2R9H2 Q52LL5 D3DX74 |
Accessions | AAD50077 EAW53868 EAW53869 Q9UNE0 AF130988 AAD50076 AI017384 AK296936 BAG59487 AK313781 BAG36519 BC093870 AAH93870 BC093872 AAH93872 CR749352 CAH18205 EU832142 ACE87492 EU832235 ACE86805 XM_006712204 XP_006712267 XM_011510502 XP_011508804 XM_011510503 XP_011508805 XM_011510504 XP_011508806 NM_022336 NP_071731 |
Function | Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines. |
Top Pathways | Cytokine-cytokine receptor interaction |
EDAR CRISPR/Cas9 KO Plasmid (h) - sc-405342 from Santa Cruz Biotechnology
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EDAR HDR Plasmid (h) - sc-405342-HDR from Santa Cruz Biotechnology
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EDAR Double Nickase Plasmid (h) - sc-405342-NIC from Santa Cruz Biotechnology
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EDAR Double Nickase Plasmid (h2) - sc-405342-NIC-2 from Santa Cruz Biotechnology
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EDAR CRISPR Activation Plasmid (h) - sc-405342-ACT from Santa Cruz Biotechnology
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EDAR CRISPR Activation Plasmid (h2) - sc-405342-ACT-2 from Santa Cruz Biotechnology
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EDAR Lentiviral Activation Particles (h) - sc-405342-LAC from Santa Cruz Biotechnology
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EDAR Lentiviral Activation Particles (h2) - sc-405342-LAC-2 from Santa Cruz Biotechnology
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EDAR siRNA (h) - sc-40239 from Santa Cruz Biotechnology
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EDAR shRNA Plasmid (h) - sc-40239-SH from Santa Cruz Biotechnology
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EDAR shRNA (h) Lentiviral Particles - sc-40239-V from Santa Cruz Biotechnology
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EDAR RNAi - H00010913-R02 from Novus Biologicals
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MISSION® esiRNA - EHU022171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7645 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7645 from Sigma-Aldrich
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EDAR siRNA (Human) - CRH7441 from Cohesion Biosciences
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EDAR - MBS8228671 from MyBioSource
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shRNA set against Human EDAR (NM_022336.3) - SHH283061 from Creative biogene
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Human EDAR siRNA - orb267943 from Biorbyt
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EDAR shRNA Plasmid (Human) - CHH7441 from Cohesion Biosciences
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