ABL1

Gene Symbol ABL1
Entrez Gene 25
Alt Symbol ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl
Species Human
Gene Type protein-coding
Description ABL proto-oncogene 1, non-receptor tyrosine kinase
Other Description Abelson tyrosine-protein kinase 1|bcr/c-abl oncogene protein|c-abl oncogene 1, receptor tyrosine kinase|proto-oncogene c-Abl|proto-oncogene tyrosine-protein kinase ABL1|tyrosine-protein kinase ABL1|v-abl Abelson murine leukemia viral oncogene homolog 1
Swissprots Q16133 Q45F09 Q13870 P00519 Q17R61 Q13869 A3KFJ3
Accessions AAA35593 AAA51895 AAB60393 AAB60394 AAD14034 AAZ38718 AHX39209 CAP08044 EAW87947 EAW87948 EAW87949 P00519 AA524892 AB209456 BAD92693 AB209642 BAD92879 AI458416 AK294983 BAG58052 AL707819 BC107069 AAI07070 BC107070 AAI07071 BC117451 AAI17452 CA335983 FJ785401 ACN82441 JF272500 ADX30694 JX565024 AFV09100 JX565025 AFV09101 M14752 AAA51561 M14753 AAA51562 M14754 AAA51563 M30833 AAA88011 X16416 CAA34438 X51945 NM_005157 NP_005148 NM_007313 NP_009297
Function Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses thro
Subcellular Location Cytoplasm, cytoskeleton. Nucleus. Mitochondrion {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed.
Top Pathways Cell cycle, Neurotrophin signaling pathway, ErbB signaling pathway, Pathogenic Escherichia coli infection, Chronic myeloid leukemia

PathScan ® Phospho-c-Abl (panTyr) Sandwich ELISA Kit - 7903 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)
Figure 1. Constitutive phosphorylation of Bcr-Abl and c-Abl in K-562 cells lysed in the presence of phosphatase inhibitors* (phospho lysate) is detected by PathScan ® Phospho-c-Abl (panTyr) Sandwich ELISA Kit #7903. In contrast, a low level of phospho-Bcr-Abl and phospho-c-Abl protein is detected in K-562 cells lysed in the absence of phosphatase inhibitors* (nonphospho lysate). Absorbance at 450 nm is shown in the top figure while corresponding western blots using c-Abl Antibody #2862 (left) and Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb #2865 (right) are shown in the bottom figure. *Phosphatase inhibitors include sodium pyrophosphate, β-glycerophosphate, and Na 3 VO 4 .

PathScan ® Phospho-c-Abl (Tyr412) Sandwich ELISA Kit - 12070 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)
Figure 1. Constitutive phosphorylation of Bcr-Abl and c-Abl in K-562 cells lysed in the presence of phosphatase inhibitors* (phospho lysate) is detected by PathScan ® Phospho-c-Abl (Tyr412) Sandwich ELISA Kit #12070. In contrast, a low level of phospho-Bcr-Abl and phospho-c-Abl protein is detected in K-562 cells lysed in the absence of phosphatase inhibitors* (nonphospho lysate). Absorbance at 450 nm is shown in the top figure while corresponding western blots using c-Abl Antibody #2862 (left panel) and Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb #2865 (right panel) are shown in the bottom figure. *Phosphatase inhibitors include sodium pyrophosphate, β-glycerophosphate, and Na 3 VO 4 .

HTScan® ABL1 Kinase Assay Kit - 7701 from Cell Signaling Technology

Category Assay Kit
Figure 5. ABL1 kinase activity was measured in a radioisotopic filtration assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 3 mM MgCl2, 3 mM MnCl2, 3 uM Na-orthovanadate, 1.2 mM DTT, ATP (variable), 2.5 ug / 50 ul PEG20.000, Substrate: PolyAEKY, 5 ug / 50 ul, Recombinant ABL1: 5 Units / 50 µl.

HTScan® Abl1 T315I Kinase Assay Kit - 7907 from Cell Signaling Technology

Category Assay Kit
Figure 1. Abl1 T315I kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 5 mM MgCl2, 5 mM MnCl2, 3 µM Na-orthovanadate, 1.2 mM DTT, 100 µM ATP, 100 µM Signal Transduction Protein (Tyr160) Biotinylated Peptide #1366 and variable amount of recombinant Abl1 T315I. Reaction mixture incubated at room temperature for 10 minutes.

HTScan® Abl1 Kinase Assay Kit - 7905 from Cell Signaling Technology

Category Assay Kit
Figure 1. Abl1 kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 5 mM MgCl2, 5 mM MnCl2, 3 µM Na-orthovanadate, 1.2 mM DTT, 100 µM ATP, 100 µM Signal Transduction Protein (Tyr160) Biotinylated Peptide (#1366) and variable amount of Recombinant Abl1. Reaction mixture incubated at room temperature for 10 minutes.

Mouse/Human/Rat Phospho-ABL1 / c-ABL (Tyr204) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1114 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-ABL1 / c-ABL (Tyr245) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1245 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human Phospho-ABL1 / c-ABL (Tyr412) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1761 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat ABL1 / c-ABL ELISA Kit (Cell-Based ELISA) - LS-F1776 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Mouse/Human/Rat Phospho-ABL1 / c-ABL (Thr735) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1674 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Rabbit anti-cAbl Antibody, Affinity Purified - PLA0203 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-cAbl Antibody, Affinity Purified: <B>Cat. No. PLA0203</B>: Detection of Human cAbl by Immunohistochemistry and Immunocytochemistry. Sample: FFPE section of Human prostate carcinoma (left) and formaldehyde-fixed K562 cells (contains the chromosomal translocation, t(9:22) that creates the BCR/ABL fusion gene) (right). Antibody: Affinity purified Rabbit Anti-cAbl (<B>Cat. No. PLA0203</B>) used at a dilution of 1:1,000 (0.2 μg/mL) and 1:200 (1 μg/mL). Detection: DAB staining and Red-fluorescent goat Anti-Rabbit IgG cross-adsorbed Antibody used at a dilution of 1:100.

Rabbit anti-cAbl Antibody, Affinity Purified - PLA0204 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-cAbl Antibody, Affinity Purified: <B>Cat. No. PLA0204</B>: Detection of Human cAbl by Immunohistochemistry and Immunocytochemistry. Sample: FFPE section of Human ovarian carcinoma (left) and formaldehyde-fixed K562 cells (contains the chromosomal translocation, t(9:22) that creates the BCR/ABL fusion gene) (right). Antibody: Affinity purified Rabbit Anti-cAbl (<B>Cat. No. PLA0204</B>) used at a dilution of 1:1,000 (1 μg/mL). Detection: DAB staining and Red-fluorescent goat Anti-Rabbit IgG cross-adsorbed Antibody used at a dilution of 1:100.

ABL1 Colorimetric Cell-Based ELISA Kit - CB5015 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

ABL1 (Phospho-Tyr204) Colorimetric Cell-Based ELISA Kit - CBP1096 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

ABL1 (Phospho-Tyr245) Colorimetric Cell-Based ELISA Kit - CBP1245 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

ABL1 (Phospho-Thr735) Colorimetric Cell-Based ELISA Kit - CBP1737 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Abl (Phospho-Tyr393/412) Colorimetric Cell-Based ELISA - CBP1866 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Abl (Phospho-Tyr412) Colorimetric Cell-Based ELISA - CBP1867 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

c-abl oncogene 1, receptor tyrosine kinase, ELISA Kit - MBS944092 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 6.25 pg/ml.
Range 25 pg/ml -1600 pg/ml.

Human Tyrosine-protein kinase ABL1(ABL1) ELISA kit - CSB-EL001105HU from Cusabio

Category ELISA Kit
Sensitivity 6.25 pg/ml
Range 25 pg/ml-1600 pg/ml

ABL1 ELISA Kit - DEIA-XYA151 from Creative Diagnostics

Category ELISA Kit

ABL1 (Phospho-Thr735) ELISA Kit - DEIA-XYA152 from Creative Diagnostics

Category ELISA Kit

ABL1 (Phospho-Tyr204) ELISA Kit - DEIA-XYA153 from Creative Diagnostics

Category ELISA Kit

ABL1 (Phospho-Tyr245) ELISA Kit - DEIA-XYA154 from Creative Diagnostics

Category ELISA Kit

Human ABL1 / c-ABL ELISA Kit (Sandwich ELISA) - LS-F27105 from LifeSpan Bioscience

Category ELISA Kit
Prices $870.00
Sizes 1 plate
Sensitivity 0.1 ng/ml
Range 2.5 - 50 ng/ml
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