ABL1

Gene Symbol	ABL1
Entrez Gene	25
Alt Symbol	ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl
Species	Human
Gene Type	protein-coding
Description	ABL proto-oncogene 1, non-receptor tyrosine kinase
Other Description	Abelson tyrosine-protein kinase 1|bcr/c-abl oncogene protein|c-abl oncogene 1, receptor tyrosine kinase|proto-oncogene c-Abl|proto-oncogene tyrosine-protein kinase ABL1|tyrosine-protein kinase ABL1|v-abl Abelson murine leukemia viral oncogene homolog 1
Swissprots	Q16133 Q45F09 Q13870 P00519 Q17R61 Q13869 A3KFJ3
Accessions	AAA35593 AAA51895 AAB60393 AAB60394 AAD14034 AAZ38718 AHX39209 CAP08044 EAW87947 EAW87948 EAW87949 P00519 AA524892 AB209456 BAD92693 AB209642 BAD92879 AI458416 AK294983 BAG58052 AL707819 BC107069 AAI07070 BC107070 AAI07071 BC117451 AAI17452 CA335983 FJ785401 ACN82441 JF272500 ADX30694 JX565024 AFV09100 JX565025 AFV09101 M14752 AAA51561 M14753 AAA51562 M14754 AAA51563 M30833 AAA88011 X16416 CAA34438 X51945 NM_005157 NP_005148 NM_007313 NP_009297
Function	Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses thro
Subcellular Location	Cytoplasm, cytoskeleton. Nucleus. Mitochondrion {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). {ECO:0000250}.
Tissue Specificity	Widely expressed.
Top Pathways	Cell cycle, Neurotrophin signaling pathway, ErbB signaling pathway, Pathogenic Escherichia coli infection, Chronic myeloid leukemia

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human c Abl (mutated T315 I) protein fragment - ab196134 from Abcam Category Protein Prices $612.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human c Abl (mutated Y253 F) protein fragment - ab140419 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human c Abl protein fragment - ab136358 from Abcam Category Protein Prices $192.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human c Abl protein fragment - ab69810 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human c Abl protein fragment - ab196111 from Abcam Category Protein Prices $612.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human c Abl protein fragment - ab157053 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Insect cells Species Human

Human c Abl peptide - ab95411 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human c Abl protein fragment - ab90193 from Abcam Category Protein Prices $235.00 Sizes 50 µg Source E. coli Species Human

ABL1 / c-ABL Antibody Blocking Peptide - LS-E2803 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ABL1 / c-ABL Antibody Blocking Peptide - LS-E7397 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ABL1 / c-ABL Antibody Blocking Peptide - LS-E7236 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ABL1 / c-ABL Antibody Blocking Peptide - LS-E7237 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ABL1 / c-ABL Antibody Blocking Peptide - LS-E9200 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ABL1 / c-ABL Antibody Blocking Peptide - LS-E9201 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ABL1 / c-ABL Antibody Blocking Peptide - LS-E9199 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

c-Abl Recombinant Protein - P4634 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

c-Abl Recombinant Protein - P4812 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant Human c-Abl Protein - P4811 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

c-Abl Recombinant Protein - P4810 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

c-Abl Recombinant Protein - P4809 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

c-Abl Recombinant Protein - P4808 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

c-Abl Recombinant Protein - P4807 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

c-Abl Recombinant Protein - P4806 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

c-Abl Recombinant Protein - P4805 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

c-Abl Peptide - P1614 from Novus Biologicals Category Peptide Species Human

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