| Gene Symbol |
ABL1
|
| Entrez Gene |
25
|
| Alt Symbol |
ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ABL proto-oncogene 1, non-receptor tyrosine kinase
|
| Other Description |
Abelson tyrosine-protein kinase 1|bcr/c-abl oncogene protein|c-abl oncogene 1, receptor tyrosine kinase|proto-oncogene c-Abl|proto-oncogene tyrosine-protein kinase ABL1|tyrosine-protein kinase ABL1|v-abl Abelson murine leukemia viral oncogene homolog 1
|
| Swissprots |
Q16133 Q45F09 Q13870 P00519 Q17R61 Q13869 A3KFJ3
|
| Accessions |
AAA35593 AAA51895 AAB60393 AAB60394 AAD14034 AAZ38718 AHX39209 CAP08044 EAW87947 EAW87948 EAW87949 P00519 AA524892 AB209456 BAD92693 AB209642 BAD92879 AI458416 AK294983 BAG58052 AL707819 BC107069 AAI07070 BC107070 AAI07071 BC117451 AAI17452 CA335983 FJ785401 ACN82441 JF272500 ADX30694 JX565024 AFV09100 JX565025 AFV09101 M14752 AAA51561 M14753 AAA51562 M14754 AAA51563 M30833 AAA88011 X16416 CAA34438 X51945 NM_005157 NP_005148 NM_007313 NP_009297
|
| Function |
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses thro
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Nucleus. Mitochondrion {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed.
|
| Top Pathways |
Cell cycle, Neurotrophin signaling pathway, ErbB signaling pathway, Pathogenic Escherichia coli infection, Chronic myeloid leukemia
|