ABL1

Gene Symbol	ABL1
Entrez Gene	25
Alt Symbol	ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl
Species	Human
Gene Type	protein-coding
Description	ABL proto-oncogene 1, non-receptor tyrosine kinase
Other Description	Abelson tyrosine-protein kinase 1|bcr/c-abl oncogene protein|c-abl oncogene 1, receptor tyrosine kinase|proto-oncogene c-Abl|proto-oncogene tyrosine-protein kinase ABL1|tyrosine-protein kinase ABL1|v-abl Abelson murine leukemia viral oncogene homolog 1
Swissprots	Q16133 Q45F09 Q13870 P00519 Q17R61 Q13869 A3KFJ3
Accessions	AAA35593 AAA51895 AAB60393 AAB60394 AAD14034 AAZ38718 AHX39209 CAP08044 EAW87947 EAW87948 EAW87949 P00519 AA524892 AB209456 BAD92693 AB209642 BAD92879 AI458416 AK294983 BAG58052 AL707819 BC107069 AAI07070 BC107070 AAI07071 BC117451 AAI17452 CA335983 FJ785401 ACN82441 JF272500 ADX30694 JX565024 AFV09100 JX565025 AFV09101 M14752 AAA51561 M14753 AAA51562 M14754 AAA51563 M30833 AAA88011 X16416 CAA34438 X51945 NM_005157 NP_005148 NM_007313 NP_009297
Function	Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses thro
Subcellular Location	Cytoplasm, cytoskeleton. Nucleus. Mitochondrion {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). {ECO:0000250}.
Tissue Specificity	Widely expressed.
Top Pathways	Cell cycle, Neurotrophin signaling pathway, ErbB signaling pathway, Pathogenic Escherichia coli infection, Chronic myeloid leukemia

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

c-Abl CRISPR/Cas9 KO Plasmid (h) - sc-400425 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Abl HDR Plasmid (h) - sc-400425-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Abl Double Nickase Plasmid (h) - sc-400425-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Abl Double Nickase Plasmid (h2) - sc-400425-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Abl CRISPR Activation Plasmid (h) - sc-400425-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Abl CRISPR Activation Plasmid (h2) - sc-400425-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Abl Lentiviral Activation Particles (h) - sc-400425-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Abl Lentiviral Activation Particles (h2) - sc-400425-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Abl siRNA (h) - sc-29843 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Abl shRNA Plasmid (h) - sc-29843-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Abl shRNA (h) Lentiviral Particles - sc-29843-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Abl siRNA (h2) - sc-44290 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Abl shRNA Plasmid (h2) - sc-44290-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Abl shRNA (h2) Lentiviral Particles - sc-44290-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Abl RNAi - H00000025-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

c-Abl RNAi - H00000025-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU141291 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK0016 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0017 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0018 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1205 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1002 from Sigma-Aldrich Category ZFN Kit

CompoZr® Knockout ZFN Kit - CKOZFN1204 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1205 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1204 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

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