| Gene Symbol |
NNT
|
| Entrez Gene |
23530
|
| Alt Symbol |
GCCD4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nicotinamide nucleotide transhydrogenase
|
| Other Description |
NAD(P) transhydrogenase, mitochondrial|pyridine nucleotide transhydrogenase
|
| Swissprots |
Q2TB60 Q13423 Q16796 Q8N3V4
|
| Accessions |
EAW56073 EAW56074 Q13423 AK297558 BAG59951 AK299622 BAG61550 AL831822 CAD38536 AM392664 CAL37542 AM393615 CAL38491 AW771969 BC032370 AAH32370 BC064402 BC110543 AAI10544 BC110544 AAI10545 BU429380 DA521839 U40490 AAC51914 Z50101 CAA90428 XM_005248274 XP_005248331 XM_005248275 XP_005248332 XM_006714461 XP_006714524 XM_011514001 XP_011512303 XM_011514002 XP_011512304 NM_012343 NP_036475 NM_182977 NP_892022
|
| Function |
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. {ECO:0000269|PubMed:22634753}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. {ECO:0000269|PubMed:22634753}.
|
| Top Pathways |
Nicotinate and nicotinamide metabolism
|