NNT

Gene Symbol NNT
Entrez Gene 23530
Alt Symbol GCCD4
Species Human
Gene Type protein-coding
Description nicotinamide nucleotide transhydrogenase
Other Description NAD(P) transhydrogenase, mitochondrial|pyridine nucleotide transhydrogenase
Swissprots Q2TB60 Q13423 Q16796 Q8N3V4
Accessions EAW56073 EAW56074 Q13423 AK297558 BAG59951 AK299622 BAG61550 AL831822 CAD38536 AM392664 CAL37542 AM393615 CAL38491 AW771969 BC032370 AAH32370 BC064402 BC110543 AAI10544 BC110544 AAI10545 BU429380 DA521839 U40490 AAC51914 Z50101 CAA90428 XM_005248274 XP_005248331 XM_005248275 XP_005248332 XM_006714461 XP_006714524 XM_011514001 XP_011512303 XM_011514002 XP_011512304 NM_012343 NP_036475 NM_182977 NP_892022
Function The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. {ECO:0000269|PubMed:22634753}.
Subcellular Location Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Tissue Specificity Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. {ECO:0000269|PubMed:22634753}.
Top Pathways Nicotinate and nicotinamide metabolism

NNT (G-8) - sc-390215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NNT (G-8): sc-390215. Western blot analysis of NNT expression in Hep G2 (A) and SW-13 (B) whole cell lysates.

NNT (B-3) - sc-390236 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NNT (B-3): sc-390236. Western blot analysis of NNT expression in Hep G2 (A) and SW-13 (B) whole cell lysates.

NNT (D-14) - sc-163154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NNT (H-300) - sc-135369 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NNT (H-300): sc-135369. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

NNT (K-15) - sc-163155 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NNT (43-R17) - sc-100490 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NNT (43-R17): sc-100490. Western blot analysis of NNT expression in non-transfected: sc-117752 (A) and human NNT transfected: sc-114805 (B) 293T whole cell lysates.

Anti-NNT antibody - ab57153 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-NNT antibody [8B4BB10] (Alexa Fluor® 488) - ab198311 from Abcam

Prices $425.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8B4BB10
ab198311 staining NNT in HeLa cells. The cells were fixed with 4% formaldehyde (10 min), permeabilised in 0.1% Triton X-100 for 5 minutes and then blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated with ab198311 at 1/100 dilution (shown in green) and ab195889, Mouse monoclonal [DM1A] to alpha Tubulin (Alexa Fluor® 594, shown in red) at 1/167 dilution overnight at +4°C. Nuclear DNA was labelled in blue with DAPI.Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-NNT Antibody (aa1-208, Azide-free) - LS-C328045 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-NNT Antibody - LS-C341001 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NNT Antibody (aa252-301) - LS-C80956 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal liver lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

NNT Antibody - NBP1-32109 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NNT Antibody [NBP1-32109] - Rat tissue extract (50 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with NNT antibody diluted at 1:1000.

NNT Antibody - NBP1-59612 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NNT Antibody [NBP1-59612] - Sample Tissue: Hela Whole cell, Lane A: Primary Antibody, Lane B:Primary Antibody + Blocking Peptide, Primary Antibody Concentration: 1ug/ml, Peptide Concentration: 5ug/ml, Lysate Quantity: 25ug/lane/Lane, Gel Concentration: 0.12

NNT Antibody (1D6) - H00023530-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D6
Western Blot: NNT Antibody (1D6) [H00023530-M01] - NNT monoclonal antibody (M01), clone 1D6 Analysis of NNT expression in HepG2.

NNT Antibody - NBP1-86512 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NNT Antibody [NBP1-86512] - Analysis in human cell line RH-30.

NNT Antibody - H00023530-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: NNT Antibody [H00023530-B01] - analysis of NNT expression in transfected 293T cell line by NNT MaxPab polyclonal antibody (B01). Lane 1: NNT transfected lysate (22.30 KDa). Lane 2: Non-transfected lysate.

NNT Antibody - H00023530-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: NNT Antibody [H00023530-D01P] - Analysis of NNT expression in human kidney.

NNT Polyclonal Antibody - bs-5097R from Bioss

Prices $279.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human kidney labeled with Rabbit Anti-NNT Polyclonal Antibody, Unconjugated (bs-5097R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-NNT antibody produced in rabbit - HPA004829 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NNT: <B>Cat. No. HPA004829</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human cerebral cortex tissue showing granular cytoplasmic staining of neuronal and non-neuronal cells.

Anti-NNT antibody produced in rabbit - SAB2101612 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-NNT: <B>Cat. No.SAB2101612</B>: NNT in Fetal Liver tissue lysate with NNT antibody at 1.0 μg/mL.

Monoclonal Anti-NNT antibody produced in mouse - WH0023530M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D6
<B>Immunoblotting</B><BR/>Monoclonal Anti-NNT, <B>Cat. No. WH0023530M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~113.8 kDa using HepG2 lysate.

Anti-NNT antibody produced in rabbit - SAB1410431 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-NNT: <B>Cat. No. SAB1410431</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~22.3 kDa using NNT transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

NNT antibody - N-terminal region (ARP46892_P050) - ARP46892_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NNT-Antibody-monoclonal-M01 - AT3073a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D6
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (48.51 KDa) .

NNT antibody - GTX103015 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-NNT antibody used in Western blot. GTX103015
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