| Gene Symbol | NNT |
|---|---|
| Entrez Gene | 23530 |
| Alt Symbol | GCCD4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nicotinamide nucleotide transhydrogenase |
| Other Description | NAD(P) transhydrogenase, mitochondrial|pyridine nucleotide transhydrogenase |
| Swissprots | Q2TB60 Q13423 Q16796 Q8N3V4 |
| Accessions | EAW56073 EAW56074 Q13423 AK297558 BAG59951 AK299622 BAG61550 AL831822 CAD38536 AM392664 CAL37542 AM393615 CAL38491 AW771969 BC032370 AAH32370 BC064402 BC110543 AAI10544 BC110544 AAI10545 BU429380 DA521839 U40490 AAC51914 Z50101 CAA90428 XM_005248274 XP_005248331 XM_005248275 XP_005248332 XM_006714461 XP_006714524 XM_011514001 XP_011512303 XM_011514002 XP_011512304 NM_012343 NP_036475 NM_182977 NP_892022 |
| Function | The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. {ECO:0000269|PubMed:22634753}. |
| Subcellular Location | Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}. |
| Tissue Specificity | Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. {ECO:0000269|PubMed:22634753}. |
| Top Pathways | Nicotinate and nicotinamide metabolism |