| Gene Symbol | CASP10 |
|---|---|
| Entrez Gene | 843 |
| Alt Symbol | ALPS2, FLICE2, MCH4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | caspase 10, apoptosis-related cysteine peptidase |
| Other Description | CASP-10|FADD-like ICE2|FAS-associated death domain protein interleukin-1B-converting enzyme 2|ICE-like apoptotic protease 4|apoptotic protease MCH-4|caspase 10, apoptosis-related cysteine protease|caspase-10|interleukin-1B-converting enzyme 2 |
| Swissprots | Q8IUP5 Q99845 Q92851 Q9Y2U7 Q68HC0 Q6KF62 Q8WYQ8 Q6KF63 Q9Y2U6 |
| Accessions | AAY24291 ABJ53426 BAB32553 BAB32554 EAW70247 EAW70248 EAW70249 EAW70250 EAW70251 Q92851 AF111344 AAD28402 AF111345 AAD28403 AI696103 AJ487678 CAD32371 AJ487679 CAD32372 AK225475 AK304859 BAG65597 AK310746 AW190618 AY690601 AAU00989 BC042844 AAH42844 BP871945 BX089180 DA456072 JF432405 ADZ15622 U60519 AAC50644 U86214 AAB46730 XM_005246907 XP_005246964 XM_005246911 XP_005246968 XM_006712796 XP_006712859 XM_011511990 XP_011510292 XR_923043 XR_923044 NM_001206524 NP_001193453 NM_001206542 NP_001193471 NM_001230 NP_001221 NM_001306083 NP_001293012 NM_032974 NP_116756 NM_032976 NP_116758 NM_032977 NP_116759 |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445}. |
| Tissue Specificity | Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. |
| Top Pathways | Apoptosis, RIG-I-like receptor signaling pathway, Tuberculosis, TNF signaling pathway |