CASP10

Gene Symbol	CASP10
Entrez Gene	843
Alt Symbol	ALPS2, FLICE2, MCH4
Species	Human
Gene Type	protein-coding
Description	caspase 10, apoptosis-related cysteine peptidase
Other Description	CASP-10|FADD-like ICE2|FAS-associated death domain protein interleukin-1B-converting enzyme 2|ICE-like apoptotic protease 4|apoptotic protease MCH-4|caspase 10, apoptosis-related cysteine protease|caspase-10|interleukin-1B-converting enzyme 2
Swissprots	Q8IUP5 Q99845 Q92851 Q9Y2U7 Q68HC0 Q6KF62 Q8WYQ8 Q6KF63 Q9Y2U6
Accessions	AAY24291 ABJ53426 BAB32553 BAB32554 EAW70247 EAW70248 EAW70249 EAW70250 EAW70251 Q92851 AF111344 AAD28402 AF111345 AAD28403 AI696103 AJ487678 CAD32371 AJ487679 CAD32372 AK225475 AK304859 BAG65597 AK310746 AW190618 AY690601 AAU00989 BC042844 AAH42844 BP871945 BX089180 DA456072 JF432405 ADZ15622 U60519 AAC50644 U86214 AAB46730 XM_005246907 XP_005246964 XM_005246911 XP_005246968 XM_006712796 XP_006712859 XM_011511990 XP_011510292 XR_923043 XR_923044 NM_001206524 NP_001193453 NM_001206542 NP_001193471 NM_001230 NP_001221 NM_001306083 NP_001293012 NM_032974 NP_116756 NM_032976 NP_116758 NM_032977 NP_116759
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445}.
Tissue Specificity	Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
Top Pathways	Apoptosis, RIG-I-like receptor signaling pathway, Tuberculosis, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence® Caspase-10 siRNA I - 6357 from Cell Signaling Technology Category siRNA

caspase-10 CRISPR/Cas9 KO Plasmid (h) - sc-416840 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

caspase-10 HDR Plasmid (h) - sc-416840-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

caspase-10 Double Nickase Plasmid (h) - sc-416840-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

caspase-10 Double Nickase Plasmid (h2) - sc-416840-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

caspase-10 CRISPR Activation Plasmid (h) - sc-416840-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

caspase-10 CRISPR Activation Plasmid (h2) - sc-416840-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

caspase-10 Lentiviral Activation Particles (h) - sc-416840-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

caspase-10 Lentiviral Activation Particles (h2) - sc-416840-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

caspase-10 siRNA (h) - sc-29923 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

caspase-10 shRNA Plasmid (h) - sc-29923-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

caspase-10 shRNA (h) Lentiviral Particles - sc-29923-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU066811 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2518 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2518 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CASP10 siRNA (Human) - CRH0597 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Caspase-10/FLICE2 RNAi - H00000843-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CASP10 - MBS8224097 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CASP10 (NM_001230.4) - SHH254937 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human CASP10(NM_032977.3) - SHG142405 from Creative biogene Category siRNA Species Reactivities Human

Human CASP10 siRNA - orb261099 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CASP10 shRNA Plasmid (Human) - CHH0597 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CASP10 miRNA 3'UTR clone - MiUTR1H-01679 from Creative biogene Species Reactivities Human

CASP10 miRNA 3'UTR clone - MiUTR1H-01680 from Creative biogene Species Reactivities Human

CASP10 miRNA 3'UTR clone - MiUTR3H-04395 from Creative biogene Species Reactivities Human

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