CASP10

Gene Symbol CASP10
Entrez Gene 843
Alt Symbol ALPS2, FLICE2, MCH4
Species Human
Gene Type protein-coding
Description caspase 10, apoptosis-related cysteine peptidase
Other Description CASP-10|FADD-like ICE2|FAS-associated death domain protein interleukin-1B-converting enzyme 2|ICE-like apoptotic protease 4|apoptotic protease MCH-4|caspase 10, apoptosis-related cysteine protease|caspase-10|interleukin-1B-converting enzyme 2
Swissprots Q8IUP5 Q99845 Q92851 Q9Y2U7 Q68HC0 Q6KF62 Q8WYQ8 Q6KF63 Q9Y2U6
Accessions AAY24291 ABJ53426 BAB32553 BAB32554 EAW70247 EAW70248 EAW70249 EAW70250 EAW70251 Q92851 AF111344 AAD28402 AF111345 AAD28403 AI696103 AJ487678 CAD32371 AJ487679 CAD32372 AK225475 AK304859 BAG65597 AK310746 AW190618 AY690601 AAU00989 BC042844 AAH42844 BP871945 BX089180 DA456072 JF432405 ADZ15622 U60519 AAC50644 U86214 AAB46730 XM_005246907 XP_005246964 XM_005246911 XP_005246968 XM_006712796 XP_006712859 XM_011511990 XP_011510292 XR_923043 XR_923044 NM_001206524 NP_001193453 NM_001206542 NP_001193471 NM_001230 NP_001221 NM_001306083 NP_001293012 NM_032974 NP_116756 NM_032976 NP_116758 NM_032977 NP_116759
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445}.
Tissue Specificity Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
Top Pathways Apoptosis, RIG-I-like receptor signaling pathway, Tuberculosis, TNF signaling pathway

Caspase-10 Antibody - 9752 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

caspase-10 (WW-H4) - sc-134299 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
caspase-10 (WW-H4): sc-134299. Western blot analysis of caspase-10 expression in U-2 OS whole cell lysate.

caspase-10 p10 (C-13) - sc-6184 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
caspase-10 p10 (C-13): sc-6184. Western blot analysis of human recombinant caspase-10 p10.

caspase-10 p10 (N-19) - sc-6186 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
caspase-10 p10 (N-19): sc-6186. Western blot analysis of caspase-10 (Mch4) precursor expression in Jurkat whole cell lysate.

caspase-10 p10 (E-11) - sc-393983 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-10 p10 (E-11): sc-393983. Western blot analysis of caspase-10 p10 expression in Jurkat (A) and Hep G2 (B) whole cell lysates and human liver tissue extract (C).

caspase-10 p20 (C-16) - sc-6185 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
caspase-10 p20 (C-16): sc-6185. Immunofluorescence staining of methanol-fixed Jurkat cells showing cytoplasmic localization.

caspase-10 p20 (H-131) - sc-7955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
caspase-10 p20 (H-131): sc-7955. Western blot analysis of human recombinant caspase-10 p20.

cleaved caspase-10 p12 (h416) - sc-22184 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Caspase-10 antibody - ab2012 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caspase-10 antibody (ab2012) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : Jurkat whole cell lysateLane 3 : A431 whole cell lysateLane 4 : K562 whole cell lysateLane 5 : NIH3T3 whole cell lysate

Anti-Caspase-10 antibody - ab155184 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caspase-10 antibody (ab155184) at 1/1000 dilutionLane 1 : Jurkat whole cell lysateLane 2 : NCI-H929 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Caspase-10 antibody - ab166722 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caspase-10 antibody (ab166722) at 1/500 dilutionLane 1 : HeLa cell extractLane 2 : HeLa cell extract with synthesized peptide

Anti-Caspase-10 antibody - ab25045 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Caspase-10 antibody (ab25045) + 2 microM/ml camptothecin treated Jurkat cells.

Anti-Caspase-10 antibody - ab52225 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caspase-10 antibody (ab52225) at 1/300 dilutionLane 1 : extracts from HeLa cells,Lane 2 : extracts from HeLa cells, with immunizing peptide

Anti-Caspase-10 antibody - ab92844 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caspase-10 antibody (ab92844) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : A431 (Human epithelial carcinoma cell line) Whole Cell LysateLane 3 : Lung (Human) Tissue LysateLane 4 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Caspase-10 antibody - ab27525 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Staining of human liver carcinoma stained using ab27525

Anti-Caspase-10 antibody - ab10452 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Caspase-10 antibody [25C2] - ab10453 from Abcam

Prices $370.00
Sizes 100 µl
Host Rat
Clonality Monoclonal
Clone 25C2

Anti-Caspase-10 antibody [2E7] - ab88066 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E7
Anti-Caspase-10 antibody [2E7] (ab88066) at 5 µg/ml + immunogen (tagged recombinant fragment) at 0.2 µg/mlSecondaryGoat anti Mouse IgG at 1/5000 dilution

Anti-Caspase-10 antibody [EPR10890] - ab177475 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10890
All lanes : Anti-Caspase-10 antibody [EPR10890] (ab177475) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-Caspase-10 antibody, prediluted - ab53646 from Abcam

Prices $370.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab53646, used neat, staining Human Caspase-10 in Liver Cancer, using Immunohistochemistry, Formalin Fixed Paraffin Embedded tissue.

Anti-pro Caspase 10 antibody [E35] - ab32155 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E35
Anti-pro Caspase 10 antibody [E35] (ab32155) at 1/1000 dilution + Hela cell lysate

Anti-CASP10 / Caspase 10 Antibody (N-Terminus) - LS-C12595 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CASP10 / Caspase 10 Antibody (Asp219) - LS-C12596 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CASP10 / Caspase 10 Antibody (aa1-15) - LS-C40710 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CASP10 / Caspase 10 Antibody (aa505-521) - LS-C261 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of caspase-10 in HeLa (H), Jurkat (J), A431 (A), K562 (K), and NIH3T3 (3T3) whole cell lysates with Caspase-10 antibody at 1:1000 dilution.
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