TNFRSF10D
| Gene Symbol | TNFRSF10D |
|---|---|
| Entrez Gene | 8793 |
| Alt Symbol | CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain |
| Other Description | TNF receptor-related receptor for TRAIL|TNF-related apoptosis-inducing ligand receptor 4|TRAIL receptor 4|TRAIL receptor with a truncated death domain|decoy receptor 2|tumor necrosis factor receptor superfamily member 10D |
| Swissprots | Q9Y6Q4 B2R8W0 Q9UBN6 |
| Accessions | CAT16465 EAW63637 Q9UBN6 AA743393 AF021232 AAC32765 AF021233 AAC32766 AF023849 AAC52053 AF029761 AAD03477 AK313528 BAG36307 AY358285 AAQ88652 BC052270 AAH52270 BU199149 CD703247 HQ448394 ADQ32874 NM_003840 NP_003831 |
| Function | Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. |
| Top Pathways | Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, Measles, Influenza A |
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