| Gene Symbol |
MED30
|
| Entrez Gene |
90390
|
| Alt Symbol |
MED30S, THRAP6, TRAP25
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mediator complex subunit 30
|
| Other Description |
TRAP/Mediator complex component TRAP25|mediator of RNA polymerase II transcription subunit 30|putative mediator of RNA polymerase II transcription subunit 30|thyroid hormone receptor associated protein 6|thyroid hormone receptor-associated protein 6|thyroid hormone receptor-associated protein complex 25 kDa component
|
| Swissprots |
C6GKU9 Q96HR3
|
| Accessions |
EAW91970 EAW91971 Q96HR3 AA812233 AW160991 AY083305 AAL89787 BC008226 AAH08226 DQ891518 ABM82444 DQ894708 ABM85634 FM179284 CAQ76893 XM_011517360 XP_011515662 NM_001282986 NP_001269915 NM_080651 NP_542382
|
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:11909976, ECO:0000269|PubMed:16595664}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:11909976}.
|
![Western Blot: MED30 Overexpression Lysate (Adult Normal) [NBL1-12991] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MED30.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3475_MED30%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12991-img0002.jpg)