Gene Symbol | MED30 |
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Entrez Gene | 90390 |
Alt Symbol | MED30S, THRAP6, TRAP25 |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 30 |
Other Description | TRAP/Mediator complex component TRAP25|mediator of RNA polymerase II transcription subunit 30|putative mediator of RNA polymerase II transcription subunit 30|thyroid hormone receptor associated protein 6|thyroid hormone receptor-associated protein 6|thyroid hormone receptor-associated protein complex 25 kDa component |
Swissprots | C6GKU9 Q96HR3 |
Accessions | EAW91970 EAW91971 Q96HR3 AA812233 AW160991 AY083305 AAL89787 BC008226 AAH08226 DQ891518 ABM82444 DQ894708 ABM85634 FM179284 CAQ76893 XM_011517360 XP_011515662 NM_001282986 NP_001269915 NM_080651 NP_542382 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:11909976, ECO:0000269|PubMed:16595664}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:11909976}. |
Med30 CRISPR/Cas9 KO Plasmid (h) - sc-406399 from Santa Cruz Biotechnology
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Med30 HDR Plasmid (h) - sc-406399-HDR from Santa Cruz Biotechnology
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Med30 Double Nickase Plasmid (h) - sc-406399-NIC from Santa Cruz Biotechnology
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Med30 Double Nickase Plasmid (h2) - sc-406399-NIC-2 from Santa Cruz Biotechnology
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Med30 CRISPR Activation Plasmid (h) - sc-406399-ACT from Santa Cruz Biotechnology
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Med30 CRISPR Activation Plasmid (h2) - sc-406399-ACT-2 from Santa Cruz Biotechnology
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Med30 Lentiviral Activation Particles (h) - sc-406399-LAC from Santa Cruz Biotechnology
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Med30 Lentiviral Activation Particles (h2) - sc-406399-LAC-2 from Santa Cruz Biotechnology
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Med30 siRNA (h) - sc-77529 from Santa Cruz Biotechnology
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Med30 shRNA Plasmid (h) - sc-77529-SH from Santa Cruz Biotechnology
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Med30 shRNA (h) Lentiviral Particles - sc-77529-V from Santa Cruz Biotechnology
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MED30 RNAi - H00090390-R01 from Novus Biologicals
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MISSION® esiRNA - EHU051471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13179 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13179 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01819 from Sigma-Aldrich
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MED30 siRNA (Human) - CRJ3940 from Cohesion Biosciences
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shRNA set against Human MED30 (NM_080651.2) - SHH340095 from Creative biogene
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Human MED30 siRNA - orb274441 from Biorbyt
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MED30 shRNA Plasmid (Human) - CHJ3940 from Cohesion Biosciences
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MED30 miRNA 3'UTR clone - MiUTR3H-11103 from Creative biogene
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