| Gene Symbol | MED30 |
|---|---|
| Entrez Gene | 90390 |
| Alt Symbol | MED30S, THRAP6, TRAP25 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mediator complex subunit 30 |
| Other Description | TRAP/Mediator complex component TRAP25|mediator of RNA polymerase II transcription subunit 30|putative mediator of RNA polymerase II transcription subunit 30|thyroid hormone receptor associated protein 6|thyroid hormone receptor-associated protein 6|thyroid hormone receptor-associated protein complex 25 kDa component |
| Swissprots | C6GKU9 Q96HR3 |
| Accessions | EAW91970 EAW91971 Q96HR3 AA812233 AW160991 AY083305 AAL89787 BC008226 AAH08226 DQ891518 ABM82444 DQ894708 ABM85634 FM179284 CAQ76893 XM_011517360 XP_011515662 NM_001282986 NP_001269915 NM_080651 NP_542382 |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:11909976, ECO:0000269|PubMed:16595664}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:11909976}. |