CARD11

Gene Symbol CARD11
Entrez Gene 84433
Alt Symbol BENTA, BIMP3, CARMA1, IMD11, PPBL
Species Human
Gene Type protein-coding
Description caspase recruitment domain family, member 11
Other Description CARD-containing MAGUK protein 1|bcl10-interacting maguk protein 3|carma 1|caspase recruitment domain-containing protein 11
Swissprots Q2NKN7 Q548H3 A4D1Z7 Q9BXL7
Accessions AAQ96893 EAL23962 EAW87276 EAW87277 EAW87278 EAW87279 Q9BXL7 AA194010 AA594170 AF322641 AAG53402 AF352576 AAL34460 AK074049 BAB84875 AK097139 AW139089 BC111719 AAI11720 HY086990 XM_011515585 XP_011513887 XM_011515586 XP_011513888 XM_011515587 XP_011513889 NM_032415 NP_115791
Function Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17287217}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Colocalized with DPP4 in membrane rafts.
Tissue Specificity Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL- 60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells. {ECO:0000269|PubMed:11278692}.
Top Pathways T cell receptor signaling pathway, B cell receptor signaling pathway

Phospho-CARD11 (Ser652) Antibody - 5189 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat cells, untreated or treated with TPA #9905 (40 nM) and calcium ionophore A23187 (2 μM) for 15 minutes, and λ-phosphatase plus calf intestinal phosphatase (CIP) as indicated, using Phospho-CARD11 (Ser652) Antibody (upper) and CARD11 (1D12) Rabbit mAb #4435 (lower).

CARD11 (1D12) Rabbit mAb - 4435 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 1D12
Western blot analysis of extracts from K562, SR and NK-92 cell lines, using CARD11 (1D12) Rabbit mAb.

CARD11 Antibody - 4440 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Raji, Jurkat, Ramos and K562 cells, using CARD11 Antibody.

CARD 11 (A-4) - sc-166910 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CARD 11 (A-4): sc-166910. Western blot analysis of CARD 11 expression in non-transfected: sc-117752 (A) and mouse CARD 11 transfected: sc-118999 (B) 293T whole cell lysates.

CARD 11 (H-300) - sc-48737 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CARD 11 (H-300): sc-48737. Western blot analysis of CARD 11 expression in non-transfected: sc-117752 (A) and mouse CARD 11 transfected: sc-118999 (B) 293T whole cell lysates.

CARD 11 (N-20) - sc-20458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CARD 11 (N-20): sc-20458. Western blot analysis of CARD 11 expression in Jurkat (A) and CCRF-CEM (B) whole cell lysates.

Anti-CARD11 antibody - ab115471 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-CARD11 antibody (ab115471) at 1 µg/ml + Jurkat cell lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-CARD11 antibody - ab64365 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CARD11 antibody (ab64365) at 1/200 dilution + NIH 3T3 whole cell lysate at 15 µg

Anti-CARD11 antibody - ab64167 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CARD11 antibody (ab64167) at 1/200 dilution + Mouse Thymus whole cell lysate at 15 µg

Anti-CARD11 antibody - ab64874 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CARD11 antibody (ab64874) at 1/500 dilutionLane 1 : Extracts from COLO205 cells with no immunising peptideLane 2 : Extracts from COLO205 cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-CARD11 antibody - ab4358 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-CARD11 antibody (ab4358) at 1 µg/ml + Human Jurkat cells (RIPA buffer, 35µg total protein per lane)

Anti-CARD11 antibody [EPR2557] - ab124730 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2557
All lanes : Anti-CARD11 antibody [EPR2557] (ab124730)Lane 1 : Molt-4 cell lysateLane 2 : Ramos cell lysateLane 3 : Jurkat cell lysateLane 4 : K562 cell lysateLysates/proteins at 10 µg per lane.

Anti-CARD11 antibody [EPR3177] - ab109310 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3177
All lanes : Anti-CARD11 antibody [EPR3177] (ab109310) at 1/1000 dilutionLane 1 : K562 cell lysates Lane 2 : Ramos cell lysates Lysates/proteins at 10 µg per lane.

Anti-CARD11 antibody - C-terminal - ab189167 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-CARD11 antibody - C-terminal (ab189167) at 0.5 µg/mlLane 2 : Anti-CARD11 antibody - C-terminal (ab189167) at 1 µg/mlLane 3 : Anti-CARD11 antibody - C-terminal (ab189167) at 2 µg/mlLane 1 : Mouse thymus cell lysateLane 2 : Mouse thymus cell lysateLane 3 : Mouse thymus cell lysate

Anti-CARMA1 / CARD11 Antibody - LS-C346250 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of A549 cell using CARD11 antibody. Blue: DAPI for nuclear staining.

Anti-CARMA1 / CARD11 Antibody (aa1-221) - LS-C344843 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry analysis of CARMA1 using anti-CARMA1, pAb (AL220) . . Method: Human T cells (clone 6396p5.1.2) were incubated with anti-CD3, mAb for 20 min. on ice, followed by incubation with secondary goat anti-mouse for 15 min. at 4°C or 37°C. Cells were stained for CD3 (green), phosphotyrosine (red) and CARMA1 (1:200 dilution; blue) and analyzed by confocal microscopy.

Anti-CARMA1 / CARD11 Antibody IHC-plus™ - LS-B4794 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CARD11 antibody IHC of human cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4794 concentration 10 ug/ml.

Anti-CARMA1 / CARD11 Antibody (C-Terminus) IHC-plus™ - LS-B471 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CARD11 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B471 concentration 5 ug/ml.

Anti-CARMA1 / CARD11 Antibody (aa1160-1171) IHC-plus™ - LS-B3030 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-CARD11 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3030 concentration 2 ug/ml.

Anti-CARMA1 / CARD11 Antibody (C-Terminus) - LS-C4322 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CARMA1 / CARD11 Antibody (aa749-765) - LS-C3234 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CARMA1 / CARD11 Antibody (aa1-221) - LS-C4323 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CARMA1 / CARD11 Antibody (Thr175) - LS-C35281 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal

Anti-CARMA1 / CARD11 Antibody (aa236-252) - LS-C147927 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CARMA1 / CARD11 Antibody (aa1072-1087) - LS-C147928 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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