| Gene Symbol |
CARD11
|
| Entrez Gene |
84433
|
| Alt Symbol |
BENTA, BIMP3, CARMA1, IMD11, PPBL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caspase recruitment domain family, member 11
|
| Other Description |
CARD-containing MAGUK protein 1|bcl10-interacting maguk protein 3|carma 1|caspase recruitment domain-containing protein 11
|
| Swissprots |
Q2NKN7 Q548H3 A4D1Z7 Q9BXL7
|
| Accessions |
AAQ96893 EAL23962 EAW87276 EAW87277 EAW87278 EAW87279 Q9BXL7 AA194010 AA594170 AF322641 AAG53402 AF352576 AAL34460 AK074049 BAB84875 AK097139 AW139089 BC111719 AAI11720 HY086990 XM_011515585 XP_011513887 XM_011515586 XP_011513888 XM_011515587 XP_011513889 NM_032415 NP_115791
|
| Function |
Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17287217}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Colocalized with DPP4 in membrane rafts.
|
| Tissue Specificity |
Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL- 60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells. {ECO:0000269|PubMed:11278692}.
|
| Top Pathways |
T cell receptor signaling pathway, B cell receptor signaling pathway
|