TTBK2

Gene Symbol TTBK2
Entrez Gene 146057
Alt Symbol SCA11, TTBK
Species Human
Gene Type protein-coding
Description tau tubulin kinase 2
Other Description tau-tubulin kinase 2
Swissprots Q8IVV1 O94932 Q6IQ55 Q6ZN52
Accessions CAD10237 EAW92581 EAW92582 EAW92583 Q6IQ55 AB020654 BAA74870 AF525400 AAO14996 AK074481 AK131372 BAD18523 BC041876 AAH41876 BC071556 AAH71556 BX648356 CB242184 DQ572375 DQ579742 DQ586356 DQ599476 XM_005254171 XP_005254228 XM_005254173 XP_005254230 XM_006720402 XP_006720465 XM_006720403 XP_006720466 XM_011521267 XP_011519569 XM_011521268 XP_011519570 XM_011521269 XP_011519571 NM_173500 NP_775771
Function Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. {ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541}.
Subcellular Location Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus. {ECO:0000250}.

SCA11 (S-17) - sc-165430 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SCA11 (S-17): sc-165430. Western blot analysis of SCA11 expression in K-562 (A) and HEK293 (B) whole cell lysates.

Anti-Tau tubulin kinase 2 antibody - ab67839 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Tau tubulin kinase 2 antibody (ab67839) at 1/500 dilutionLane 1 : Tau tubulin kinase 2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-Tau tubulin kinase 2 antibody - ab140202 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human placenta tissue labelling Tau tubulin kinase 2 with ab140202 at 5 µg/ml.

Anti-Tau tubulin kinase 2 antibody - N-terminal - ab170799 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of K562 cells labeling Tau tubulin kinase 2 using ab170799 at a 1/10 dilution (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used .

Anti-TTBK2 Antibody (aa217-245, AP) - LS-C218199 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTBK2 Antibody (aa217-245, APC) - LS-C218201 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTBK2 Antibody (aa217-245, Azide-free, HRP) - LS-C218204 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTBK2 Antibody (aa217-245, Biotin) - LS-C218202 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTBK2 Antibody (aa217-245, PE) - LS-C218205 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTBK2 Antibody (aa217-245, FITC) - LS-C218203 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTBK2 Antibody (aa224-253) - LS-C326071 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTBK2 Antibody (aa270-319) - LS-C145437 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TTBK2 antibody LS-C145437 Western blot of Mouse Thymus lysate. Antibody concentration 1 ug/ml.

Anti-TTBK2 Antibody (aa217-245) - LS-C160285 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TTBK2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lung tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-TTBK2 Antibody (C-Terminus) IHC-plus™ - LS-B4716 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TTBK2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4716 concentration 10 ug/ml.

Tau tubulin kinase 2 Antibody - NBP1-92476 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Tau tubulin kinase 2 Antibody [NBP1-92476] - Staining of human testis shows moderate cytoplasmic positivity in spermatids and sperm.

Tau tubulin kinase 2 Antibody - NBP1-72002 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Tau tubulin kinase 2 Antibody [NBP1-72002] - Staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Tau tubulin kinase 2 Antibody - H00146057-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Tau tubulin kinase 2 Antibody [H00146057-B01P] - Analysis of TTBK2 expression in K-562.

TTBK2/SCA11 Polyclonal Antibody - bs-11771R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TTBK2/SCA11 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11771R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TTBK2/SCA11 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11771R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TTBK2/SCA11 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11771R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TTBK2/SCA11 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11771R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TTBK2/SCA11 Polyclonal Antibody, Cy3 Conjugated - bs-11771R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TTBK2/SCA11 Polyclonal Antibody, Cy5 Conjugated - bs-11771R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TTBK2/SCA11 Polyclonal Antibody, Cy5.5 Conjugated - bs-11771R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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